4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride
- Product Name
- 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride
- CAS No.
- 1027345-07-8
- Chemical Name
- 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride
- Synonyms
- EOS-62147;4-fluoro-3-(trifuoromethylsulfonyl)benzenesulfonyl chlo;4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride;4-Fluoro-3-[(trifluoromethyl)sulphonyl]benzenesulphonyl chloride;Benzenesulfonyl chloride, 4-fluoro-3-[(trifluoromethyl)sulfonyl]-;4-fluoro-3-((trifluoroMethyl)sulfonyl)benzene-1-sulfonyl chloride
- CBNumber
- CB82520214
- Molecular Formula
- C7H3ClF4O4S2
- Formula Weight
- 326.67
- MOL File
- 1027345-07-8.mol
4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride Property
- Boiling point:
- 397.1±42.0 °C(Predicted)
- Density
- 1.733±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- color
- Clear, pale amber/ lime
Safety
- HS Code
- 2904990090
N-Bromosuccinimide Price
- Product number
- F401923
- Product name
- 4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonylChloride
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC502180
- Product name
- 4-Fluoro-3-[(trifluoromethyl)sulphonyl]benzenesulphonyl chloride
- Packaging
- 250mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 6663-7-11
- Product name
- 4-Fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonyl chloride
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 0662AA
- Product name
- 4-Fluoro-3-((trifluoromethyl)sulfonyl)benzene-1-sulfonylchloride
- Packaging
- 250mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- PC502180
- Product name
- 4-Fluoro-3-[(trifluoromethyl)sulphonyl]benzenesulphonyl chloride
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride Chemical Properties,Usage,Production
Synthesis
2358-41-0
1027345-07-8
General procedure for the synthesis of 3-(trifluoromethylsulfonyl)-4-fluorobenzenesulfonyl chloride from 1-fluoro-2-(trifluoromethanesulfonyl)benzene: 1-fluoro-2-(trifluoromethanesulfonyl)benzene (10.00 g, 43.83 mmol) was dissolved in chlorosulfuric acid (35.00 mL) and the reaction was heated for 5 hours at 120°C. After the reaction was completed, the mixture was slowly poured into a mixture consisting of crushed ice (100 g) and water (300 mL). The reaction mixture was extracted with dichloromethane (80 mL x 2) and the combined organic phases were washed with distilled water (200 mL x 2). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 3-(trifluoromethylsulfonyl)-4-fluorobenzenesulfonyl chloride (12.60 g, 38.57 mmol, 88% yield), which could be used for the next reaction without further purification. Mass spectrum (ESI) m/z = 307 [M-Cl+OH-H]. 1H NMR (400 MHz, DMSO-d6): δ 8.25 (m, 1H), 8.15 (m, 1H), 7.73 (m, 1H).
References
[1] Patent: WO2017/101851, 2017, A1. Location in patent: Paragraph 0135; 0138
[2] Patent: WO2008/61208, 2008, A2. Location in patent: Page/Page column 30-31
[3] Synthesis, 2008, # 15, p. 2398 - 2404
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 21, p. 6902 - 6915
[5] Patent: US2009/318689, 2009, A1. Location in patent: Page/Page column 34
4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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