N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide

Product Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
CAS No.: 215803-78-4
Chemical Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
Synonyms: CS-413;SB-277011;SB-277011A;SB277011,SB 277011;SB-277011, 10 mM in DMSO;SB-277011-A;SB-277011A;SB277011;SB 277011;N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide;N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-
CBNumber: CB82521231
Molecular Formula: C28H30N4O
Formula Weight: 439
MOL File: 215803-78-4.mol

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N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Property

Boiling point:: 679.3±55.0 °C(Predicted)
Density: 1.23
storage temp.: Store at -20°C
solubility: DMSO
form: Powder
pka: 13.47±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006979
Product name: SB-277011-A
Purity: 95.00%
Packaging: 250MG
Price: $271.95
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611366
Product name: SB-277011
Packaging: 100mg
Price: $765
Updated: 2021/12/16

Chemenu

Product number: CM146156
Product name: N-(trans-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide
Purity: 98%
Packaging: 10mg
Price: $204
Updated: 2021/12/16

Crysdot

Product number: CD31002666
Product name: SB-277011
Purity: 98+%
Packaging: 10mg
Price: $335
Updated: 2021/12/16

Chemenu

Product number: CM146156
Product name: N-(trans-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide
Purity: 98%
Packaging: 50mg
Price: $462
Updated: 2021/12/16

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N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Chemical Properties,Usage,Production

Uses

SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant. IC50 value: 8.0 (pKi) Target: D3 receptor

References

[1] Clément P, Pozzato C, Heidbreder C, Alexandre L, Giuliano F, Melotto S.Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat.J Sex Med. 2009 Apr;6(4):980-8. Epub 2008 Feb 4. DOI:10.1111/j.1743-6109.2008.01173.x
[2] Gyertyán I, Sághy K.The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats.Eur J Pharmacol. 2007 Oct 31;572(2-3):171-4. Epub 2007 Jun 29. DOI:10.1016/j.ejphar.2007.06.035
[3] Southam E, Lloyd A, Jennings CA, Cluderay JE, Cilia J, Gartlon JE, Jones DN.Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.Brain Res. 2007 May 29;1149:50-7. Epub 2007 Feb 28. DOI:10.1016/j.brainres.2007.02.051
[4] Pak AC, Ashby CR Jr, Heidbreder CA, Pilla M, Gilbert J, Xi ZX, Gardner EL.The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.Int J Neuropsychopharmacol. 2006 Oct; DOI:10.1017/S1461145706006560
[5] Higley, Amanda E.; Kiefer, Stephen W.; Li, Xia; Gaal, Jozsef; Xi, Zheng-Xiong; Gardner, Eliot L. Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. Eur

N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Suppliers

China 31 The Netherlands 1 United States 6 Global 38

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215803-78-4, N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamideRelated Search:

N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide

SB-277011

SB-277011A

CS-413

N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide

SB-277011-A;SB-277011A;SB277011;SB 277011

4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-

SB277011,SB 277011

SB-277011, 10 mM in DMSO

215803-78-4

C28H30N4OClH