N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
- Product Name
- N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
- CAS No.
- 215803-78-4
- Chemical Name
- N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide
- Synonyms
- CS-413;SB-277011;SB-277011A;SB277011,SB 277011;SB-277011, 10 mM in DMSO;SB-277011-A;SB-277011A;SB277011;SB 277011;N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide;N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide;4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-
- CBNumber
- CB82521231
- Molecular Formula
- C28H30N4O
- Formula Weight
- 439
- MOL File
- 215803-78-4.mol
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Property
- Boiling point:
- 679.3±55.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- Store at -20°C
- solubility
- DMSO
- form
- Powder
- pka
- 13.47±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- API0006979
- Product name
- SB-277011-A
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $271.95
- Updated
- 2021/12/16
- Product number
- orb611366
- Product name
- SB-277011
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- CD31002666
- Product name
- SB-277011
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $855
- Updated
- 2021/12/16
- Product number
- CM146156
- Product name
- N-(trans-4-(2-(6-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)quinoline-4-carboxamide
- Purity
- 98%
- Packaging
- 10mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CD31002666
- Product name
- SB-277011
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $335
- Updated
- 2021/12/16
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Chemical Properties,Usage,Production
Uses
SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant. IC50 value: 8.0 (pKi) Target: D3 receptor
References
[1] Clément P, Pozzato C, Heidbreder C, Alexandre L, Giuliano F, Melotto S.Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat.J Sex Med. 2009 Apr;6(4):980-8. Epub 2008 Feb 4. DOI:10.1111/j.1743-6109.2008.01173.x
[2] Gyertyán I, Sághy K.The selective dopamine D3 receptor antagonists, SB 277011-A and S 33084 block haloperidol-induced catalepsy in rats.Eur J Pharmacol. 2007 Oct 31;572(2-3):171-4. Epub 2007 Jun 29. DOI:10.1016/j.ejphar.2007.06.035
[3] Southam E, Lloyd A, Jennings CA, Cluderay JE, Cilia J, Gartlon JE, Jones DN.Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain.Brain Res. 2007 May 29;1149:50-7. Epub 2007 Feb 28. DOI:10.1016/j.brainres.2007.02.051
[4] Pak AC, Ashby CR Jr, Heidbreder CA, Pilla M, Gilbert J, Xi ZX, Gardner EL.The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions.Int J Neuropsychopharmacol. 2006 Oct; DOI:10.1017/S1461145706006560
[5] Higley, Amanda E.; Kiefer, Stephen W.; Li, Xia; Gaal, Jozsef; Xi, Zheng-Xiong; Gardner, Eliot L. Dopamine D3 receptor antagonist SB-277011A inhibits methamphetamine self-administration and methamphetamine-induced reinstatement of drug-seeking in rats. Eur
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide Suppliers
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