GSK1292263

Product Name: GSK1292263
CAS No.: 1032823-75-8
Chemical Name: GSK1292263
Synonyms: CS-417;GSK1292263;GSK1292263 USP/EP/BP;GSK-1292263;GSK 1292263;GPR119 receptor agonist GS1292263;GPR119 Agonist II GSK1292263 GSK-1292263;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxa;5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)pyridine;3-isopropyl-5-(4-(((6-(4-(Methylsulfonyl)phenyl)pyridin-3-yl)oxy)Methyl)piperidin-1-yl)-1,2,4-oxadiazole
CBNumber: CB82522975
Molecular Formula: C23H28N4O4S
Formula Weight: 456.56
MOL File: 1032823-75-8.mol

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GSK1292263 Property

Boiling point:: 655.1±65.0 °C(Predicted)
Density: 1.23
storage temp.: Store at -20°C
solubility: ≥21.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 4.75±0.32(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26181
Product name: GSK1292263
Packaging: 5mg
Price: $119
Updated: 2024/03/01

Cayman Chemical

Product number: 26181
Product name: GSK1292263
Packaging: 50mg
Price: $813
Updated: 2024/03/01

Cayman Chemical

Product number: 26181
Product name: GSK1292263
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 26181
Product name: GSK1292263
Packaging: 25mg
Price: $501
Updated: 2024/03/01

ChemScene

Product number: CS-0228
Product name: GSK1292263
Purity: 99.71%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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GSK1292263 Chemical Properties,Usage,Production

Biological Activity

gsk1292263 is a novel agonist of gpr119 receptor agonist and is used for the treatment of type 2 diabetes.gpr119 is described as a class a (rhodopsin-type) orphan gpcr with no close primary sequence relative in the human genome. the activation of gpr119 increases the intracellular accumulation of camp, resulting in enhanced insulin secretion from pancreatic β-cells and increased release of the gut peptides glp-1 (glucagon-like peptide 1), gip (glucose-dependent insulinotropic peptide) and pyy (polypeptide yy).in vitro, gsk1292263 treatment displayed little inhibition towards cyps (cyp1a2, 2c9, 2c19, 2d6, 3a4), p-gp, oatp1b3, or oct2. however, gsk1292263 inhibited bcrp and oatp1b1, which are transporters involved in statin disposition 1.in the glucose tolerance test in rats, administration of gsk-1292263 significantly increases the peak insulin response and insulin auc (0-15 min) as compared with the values in the vehicle control. the upregulation of insulin was found to correlate with an increase in the glucose disposal rate. in hyperinsulinemic-euglycemic clamps, gsk-1292263 administration on sprague-dawley rats at dose of 10 or 30 mg/kg 2 hours prior to insulin infusion can promote glucagon secretion with no increase of blood glucose levels 2.

target

GPR119

References

1. polli jw, hussey e, bush m, et al. evaluation of drug interactions of gsk1292263 (a gpr119 agonist) with statins: from in vitro data to clinical study design. xenobiotica; the fate of foreign compounds in biological systems. 2013;43(6):498-508.2. zhu x, huang d, lan x, et al. the first pharmacophore model for potent g protein-coupled receptor 119 agonist. european journal of medicinal chemistry. 2011;46(7):2901-2907.

GSK1292263 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK1292263 Suppliers

China 99 India 1 United Kingdom 1 United States 11 Global 112

AdooQ BioScience, LLC

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View Lastest Price from GSK1292263 manufacturers

Career Henan Chemical Co

Product: GSK1292263 1032823-75-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

1032823-75-8, GSK1292263Related Search:

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CS-417

GPR119 receptor agonist GS1292263

3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-

5-[[[1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methyl]oxy]-2-[4-(methylsulfonyl)phenyl]pyridine

3-isopropyl-5-(4-(((6-(4-(Methylsulfonyl)phenyl)pyridin-3-yl)oxy)Methyl)piperidin-1-yl)-1,2,4-oxadiazole

3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxa

GSK1292263

5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)pyridine

5-[[[1-[3-(1-Methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methyl]oxy]-2-[4-(methylsulfonyl)phenyl]pyridine gsk 1292263

GSK-1292263;GSK 1292263

Pyridine, 5-[[1-[3-(1-methylethyl)-1,2,4-oxadiazol-5-yl]-4-piperidinyl]methoxy]-2-[4-(methylsulfonyl)phenyl]-

GSK1292263 USP/EP/BP

GPR119 Agonist II GSK1292263 GSK-1292263

1032823-75-8

Inhibitors