2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester

Uses

Product Name: 2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester
CAS No.: 1211526-53-2
Chemical Name: 2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester
Synonyms: 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid;2-Boc-2-aza-spiro[3.3]heptane-6-carboxylic acid;2-Boc-2-aza-spiro[3.3]hep...;N-Boc-2-azaspiro[3.3]heptane-6-carboxylic Acid;2-Boc-2-aza-spiro[3.3]hep... ISO 9001：2015 REACH;6-tert-Butoxycarbonyl-6-azaspiro[3.3]heptane-2-carboxylic acid;2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid 2-tert-butyl ester;2-[(tert-butoxy)carbonyl]-2-azaspiro[3.3]heptane-6-carboxyli...;2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid 2-tert-butyl ester - A6137;2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester
CBNumber: CB82525693
Molecular Formula: C12H19NO4
Formula Weight: 241.28
MOL File: 1211526-53-2.mol

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2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester Property

Melting point:: 95-97 °C(Solv: ethanol (64-17-5))
Boiling point:: 377.4±42.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
form: solid
pka: 4.58±0.20(Predicted)
color: White
InChI: InChI=1S/C12H19NO4/c1-11(2,3)17-10(16)13-6-12(7-13)4-8(5-12)9(14)15/h8H,4-7H2,1-3H3,(H,14,15)
InChIKey: SZAAHQWPPBNUQR-UHFFFAOYSA-N
SMILES: C1C2(CC(C(O)=O)C2)CN1C(OC(C)(C)C)=O

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B811055
Product name: 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylicAcid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR308108
Product name: 2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylicacid
Purity: 97%
Packaging: 250mg
Price: $167
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-Q6
Product name: 2-Boc-2-azaspiro[3.3]heptane-6-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $184
Updated: 2021/12/16

Synthonix

Product number: A6137
Product name: 2-Azaspiro[3.3]heptane-2,6-dicarboxylicacid2-tert-butylester
Purity: 97.0%
Packaging: 1g
Price: $330
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0388633
Product name: 2-(TERT-BUTOXYCARBONYL)-2-AZASPIRO[3.3]HEPTANE-6-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $505.41
Updated: 2021/12/16

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2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester Chemical Properties,Usage,Production

Uses

2-BOC-2-azaspiro[3.3]heptane-6-carboxylic acid is an important pharmaceutical intermediate and a key raw material for the synthesis of many drugs and excipients. It is used in the preparation of some protein kinase inhibitors, etc.

Synthesis

1374658-94-2

1211526-53-2

General procedure for the synthesis of 2-BOC-2-azaspiro[3.3]heptane-6-carboxylic acid from tert-butyl 6-cyano-2-azaspiro[3.3]heptane-2-carboxylate: 6-cyano-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester (2.0 g, 9.0 mmol) was dissolved in a mixed solvent of ethanol (40 mL) and water (40 mL), followed by addition of potassium hydroxide (2.0 g, 36.0 mmol). The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate, v/v=1/1, Rf=0.0) and after confirming the completion of the reaction, most of the ethanol was removed by concentration under reduced pressure. The pH of the remaining solution was adjusted to 3-4 with 1N hydrochloric acid and the aqueous phase was extracted with dichloromethane. The organic phase was dried over anhydrous sodium sulfate and subsequently concentrated to dryness under reduced pressure to afford 2-BOC-2-azaspiro[3.3]heptane-6-carboxylic acid (1.3 g, 62% yield).

References

[1] Patent: CN105646318, 2016, A. Location in patent: Paragraph 0009

2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester Suppliers

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View Lastest Price from 2-Azaspiro[3.3]heptane-2,6-dicarboxylic acid, 2-(1,1-dimethylethyl) ester manufacturers

Career Henan Chemical Co

Product: 2-Boc-2-aza-spiro[3.3]hep... 1211526-53-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-02

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