5,6-DiMethoxyindoline
- Product Name
- 5,6-DiMethoxyindoline
- CAS No.
- 15937-07-2
- Chemical Name
- 5,6-DiMethoxyindoline
- Synonyms
- 5,6-DiMethoxyindoline;5,6-diMethoxy-2,3-dihydro-1H-indole;2,3-dihydro-5,6-diMethoxy-1H-Indole;1H-INDOLE, 2,3-DIHYDRO-5,6-DIMETHOXY;6-broMo-7-MethyliMidazo[1,2-b]pyridazine
- CBNumber
- CB82526276
- Molecular Formula
- C10H13NO2
- Formula Weight
- 179.22
- MOL File
- 15937-07-2.mol
5,6-DiMethoxyindoline Property
- Melting point:
- 105℃ (benzene )
- Boiling point:
- 301.2±42.0 °C(Predicted)
- Density
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 5.72±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D470553
- Product name
- 5,6-Dimethoxyindoline
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD154938
- Product name
- 5,6-Dimethoxyindoline
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FD154938
- Product name
- 5,6-Dimethoxyindoline
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CHM0383529
- Product name
- 5,6-DIMETHOXYINDOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.51
- Updated
- 2021/12/16
- Product number
- FD154938
- Product name
- 5,6-Dimethoxyindoline
- Packaging
- 500mg
- Price
- $600
- Updated
- 2021/12/16
5,6-DiMethoxyindoline Chemical Properties,Usage,Production
Uses
5,6-Dimethoxyindoline is used in preparation of Biphenyl derivatives for treating obstructive airways disease.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 21, p. 548, 1978 DOI: 10.1021/jm00204a009
Synthesis
63375-81-5
15937-07-2
The general procedure for the synthesis of 5,6-dimethoxyindoline from 2-(2-bromo-4,5-dimethoxyphenyl)ethanamine hydrochloride was as follows: to a sealed round-bottom flask under nitrogen protection were added cuprous iodide (CuI, 0.11 g, 0.55 mmol), L-proline (0.13 g, 1.1 mmol) and potassium carbonate (K2CO3, 1.62 g, 11.1 mmol). 11.1 mmol). The system was evacuated and backfilled with nitrogen and the process was repeated twice. Subsequently, a dimethyl sulfoxide (DMSO, 5.5 mL) solution of 2-(2-bromo-4,5-dimethoxyphenyl)ethylamine (1.45 g, 5.5 mmol) was added and the reaction was stirred at 70 °C for 45 h under nitrogen atmosphere. After completion of the reaction, water (100 mL) was added to the mixture and extracted with chloroform (CHCl3, 3 x 100 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), concentrated and purified by short-range chromatographic column with chloroform/methanol (60:1) as eluent to afford the target product 5,6-dimethoxyindoline (0.36 g, 36% yield) as a light brown solid. The product was characterized by 1H NMR (CDCl3): δ 6.76 (s, 1H), 6.35 (s, 1H), 3.82 (s, 3H), 3.81 (s, 3H), 3.54 (t, J = 8.4 Hz, 2H), 2.98 (t, J = 8.4 Hz, 2H). The data obtained are in agreement with the spectral data of the compounds prepared by other methods.
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 6, p. 1852 - 1859
5,6-DiMethoxyindoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,6-DiMethoxyindoline manufacturers
- Product
- 5,6-DiMethoxyindoline 15937-07-2
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12