tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate
- Product Name
- tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate
- CAS No.
- 121496-39-7
- Chemical Name
- tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate
- Synonyms
- N-Boc-benzyl-ethanol amine;2-(Benzyl-Boc-amino)ethanol;tertbutylbenzylhydroxyethylcarbamate;tert-butyl benzyl(2-hydroxyethyl)carbamate;N-tert.-Butoxycarbonyl-N-benzyl-ethanolamine;tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate;Carbamic acid, N-(2-hydroxyethyl)-N-(phenylmethyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB82527091
- Molecular Formula
- C14H21NO3
- Formula Weight
- 251.32
- MOL File
- 121496-39-7.mol
tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate Property
- Boiling point:
- 372.9±31.0 °C(Predicted)
- Density
- 1.094±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.66±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B416668
- Product name
- tert-ButylN-Benzyl-N-(2-hydroxyethyl)carbamate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B416668
- Product name
- tert-ButylN-Benzyl-N-(2-hydroxyethyl)carbamate
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 054336
- Product name
- tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 054336
- Product name
- tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate
- Purity
- >95%
- Packaging
- 1g
- Price
- $228
- Updated
- 2021/12/16
- Product number
- 3906AA
- Product name
- tert-ButylN-benzyl-N-(2-hydroxyethyl)carbamate
- Packaging
- 1g
- Price
- $313
- Updated
- 2021/12/16
tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate Chemical Properties,Usage,Production
Synthesis
24424-99-5
104-63-2
121496-39-7
General procedure for the synthesis of tert-butyl benzyl (2-hydroxyethyl) carbamate from di-tert-butyl dicarbonate and N-benzylethanolamine: a solution of di-tert-butyl dicarbonate (0.01 mol) in dichloromethane (15 mL) was added slowly and dropwise to a mixture containing 2-benzylaminoethanol (0.01 mol), dichloromethane (15 mL), and a 1 M aqueous sodium hydroxide solution (12 mL). . The reaction mixture was stirred at room temperature for 24 hours. After completion of the reaction, the organic layer was separated, washed sequentially with water (25 mL × 2) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product as an oil. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether: ethyl acetate (7:3, v/v) to obtain the target product tert-butyl benzyl (2-hydroxyethyl)carbamate in 100% yield.
References
[1] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 3, p. 295 - 300
[2] Journal of Organic Chemistry, 2000, vol. 65, # 20, p. 6368 - 6380
[3] Patent: WO2005/26111, 2005, A2. Location in patent: Page/Page column 17
[4] Patent: WO2008/42353, 2008, A1. Location in patent: Page/Page column 19; 21
[5] Patent: TW2016/2105, 2016, A. Location in patent: Paragraph 0563
tert-Butyl N-benzyl-N-(2-hydroxyethyl)carbamate Preparation Products And Raw materials
Raw materials
Preparation Products
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