ChemicalBook > CAS DataBase List > 2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline

Product Name
2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline
CAS No.
898563-00-3
Chemical Name
2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline
Synonyms
TP-10;TP-10, 10 mM in DMSO;2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline;2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline;2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline;Quinoline, 2-[[4-[4-(4-pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenoxy]methyl]-;schizophrenia,U-87 MG,TP 10,cGMP,TP10,inhibit,TP-10,disorder,Inhibitor,cAMP,reactive oxygen,Phosphodiesterase (PDE),pCREB-LI
CBNumber
CB82535186
Molecular Formula
C26H19F3N4O
Formula Weight
460.45
MOL File
898563-00-3.mol
More
Less

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Property

Boiling point:
564.4±50.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 100 mg/mL (217.18 mM);Water : < 0.1 mg/mL (insoluble)
pka
4.08±0.10(Predicted)
form 
Solid
color 
Light yellow to brown
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-5242
Product name
TP-10
Purity
98.54%
Packaging
5mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0316639
Product name
TP-10
Purity
95.00%
Packaging
5MG
Price
$499.36
Updated
2021/12/16
ChemScene
Product number
CS-5242
Product name
TP-10
Purity
98.54%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-5242
Product name
TP-10
Purity
98.54%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-5242
Product name
TP-10
Purity
98.54%
Packaging
100mg
Price
$2520
Updated
2021/12/16
More
Less

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Chemical Properties,Usage,Production

Description

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.IC50 value: 0.8 nM [1]Target: PDE10ATP-10 has extremely potent PDE10A inhibitory activity and highselectivity against other PDEs, and be active in the mouse behavioral model for positive symptoms. TP-10 demonstrats good in vitro and in vivo activity, the intrinsic clearance (CLint) of these compounds in mouse liver microsomes (MLM) was extremely high in assay (CLint>1000 mL/min/kg). [1]

Uses

TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy[1][2][3].

in vivo

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides[2].

Animal Model:Male CD rats[2]
Dosage:0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration:Subcutaneous injection; 0.1-10 mg/kg once
Result:Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.

References

[1]. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213. [2]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline Suppliers

China 31 United States 5 Global 36
Hefei novabio-chem Biotechnology Co., Ltd.
Tel
0551-62626599 19956094396
Email
sales@bankpeptide.com
Country
China
ProdList
974
Advantage
58
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1618
Advantage
59
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9751
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7587
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Zhende Chemical Technology (Shanghai) Co., Ltd.
Tel
15601952568
Fax
3004479441
Email
sales4@myuchem.com
Country
China
ProdList
2988
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7986
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
7048
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
15387063101
Email
2881924050@qq.com
Country
China
ProdList
9960
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Guangzhou Chengchuang Biotechnology Co., Ltd.
Tel
18027266590
Email
2377736726@qq.com
Country
China
ProdList
500
Advantage
58
Xianning Shen Lan Biomedical Research and Development Co., Ltd.
Tel
18171815831
Email
1341138380@qq.com
Country
China
ProdList
4310
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525 17316404525
Email
209533805@qq.com
Country
China
ProdList
9766
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Guangzhou Weike Biotechnology Co., Ltd.
Tel
15902098758
Country
CHINA
ProdList
133
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Qiming Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6502
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
--
Fax
--
Email
kexianxun@gmail.com
Country
China
ProdList
1037
Advantage
50

898563-00-3, 2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinolineRelated Search:


  • 2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline
  • TP-10
  • 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline
  • 2-({4-[4-(4-Pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]p henoxy}methyl)quinoline
  • Quinoline, 2-[[4-[4-(4-pyridinyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
  • schizophrenia,U-87 MG,TP 10,cGMP,TP10,inhibit,TP-10,disorder,Inhibitor,cAMP,reactive oxygen,Phosphodiesterase (PDE),pCREB-LI
  • TP-10, 10 mM in DMSO
  • 898563-00-3