A 1120

Product Name: A 1120
CAS No.: 1152782-19-8
Chemical Name: A 1120
Synonyms: A 1120;A-1120,Inhibitor,inhibit,A 1120,A1120;2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid;2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid;Benzoic acid, 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-
CBNumber: CB82535656
Molecular Formula: C20H19F3N2O3
Formula Weight: 392.37
MOL File: 1152782-19-8.mol

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A 1120 Property

Boiling point:: 572.3±50.0 °C(Predicted)
Density: 1.370±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 100 mM; Ethanol: 25 mM
form: powder
pka: 4.03±0.36(Predicted)
color: off-white

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-36-43-50/53
Safety Statements: 26-36/37-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3111
Product name: A1120
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: A3111
Product name: A1120
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $563
Updated: 2024/03/01

Tocris

Product number: 3793
Product name: A1120
Purity: ≥99%(HPLC)
Packaging: 50
Price: $785
Updated: 2021/12/16

Tocris

Product number: 3793
Product name: A1120
Purity: ≥99%(HPLC)
Packaging: 10
Price: $186
Updated: 2021/12/16

TRC

Product number: A965350
Product name: A1120
Packaging: 2.5mg
Price: $220
Updated: 2021/12/16

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A 1120 Chemical Properties,Usage,Production

Uses

A 1120 is a a nonretinoid RBP4 antagonist, which inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis.

Biochem/physiol Actions

A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.

storage

Store at RT

A 1120 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 1120 Suppliers

China 31 United Kingdom 1 United States 10 Global 42

Shanghai EFE Biological Technology Co., Ltd.

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View Lastest Price from A 1120 manufacturers

Career Henan Chemica Co

Product: A 1120 1152782-19-8
Price: US $0.80-1.80/KG
Min. Order: 1KG
Purity: 95%~99.99%
Supply Ability: 10 MT/ Month
Release date: 2020-11-04

1152782-19-8, A 1120Related Search:

A 1120

2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Benzoic acid, 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-

A-1120,Inhibitor,inhibit,A 1120,A1120

2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid

1152782-19-8