ChemicalBook > CAS DataBase List > AS 1269574

AS 1269574

Product Name: AS 1269574
CAS No.: 330981-72-1
Chemical Name: AS 1269574
Synonyms: AS126957;AS 1269574;AS1269574 ，E0347;AS-1269574 (AS1269574);AS1269574, 10 mM in DMSO;GPR119 Agonist, AS1269574;2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol;2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol;Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-
CBNumber: CB82535661
Molecular Formula: C13H14BrN3O
Formula Weight: 308.17
MOL File: 330981-72-1.mol

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AS 1269574 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solution in ethanol
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 371724
Product name: GPR119 Agonist, AS1269574
Purity: The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging: 10MG
Price: $145
Updated: 2025/07/31

Cayman Chemical

Product number: 10626
Product name: AS-1269574
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10626
Product name: AS-1269574
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 10626
Product name: AS-1269574
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10626
Product name: AS-1269574
Purity: ≥98%
Packaging: 25mg
Price: $257
Updated: 2024/03/01

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AS 1269574 Chemical Properties,Usage,Production

Uses

Acts as an orally available agonist of GPR119 (G-protein coupled receptor 119), a regulator of incretin and insulin hormone secretion.

Biological Activity

as 1269574,(2-[2-(4-bromophenyl)-6-methylpyrimidin-4-yl] amino ethanol), was capable of inducing glucose-stimulated insulin secretion (gsis) and improved glucose tolerance in normal mice. as 1269574 is an agonist of gpr119 with ec50 value of 2.5 μm [1] [2].gpr119 is highly expressed in pancreatic β-cells. this receptor enhances the effect of gsis via the elevation of intracellular camp concentrations [2].treated with either 1 or 10 μm as 1269574 for 20 min, the insulin secretion of mouse pancreatic min-6 β-cells pre-exposed to 16.8 mm glucose was significantly increased compared with the dmso vehicle control. in contrast, as 1269574 did not affect the insulin release of min-6 cells previously treated with low-glucose (2.8 mm) [2].in normal mice, a single treatment with 100 mg/kg of as 1269574 significantly reduced the area under the curve (auc) after 2 h (auc0-2h) of blood glucose. as 1269574 significantly increase the plasma insulin auc0-2h in mice compared with the vehicle control. a single oral administration of 100 mg/kg as 1269574 did not significantly lower the blood glucose auc in either fasted or fed mice, indicating as 1269574 did not have a hypoglycemic effect [2].

in vivo

AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC_0-2h) of administration^[1].

Animal Model:	Eight-week-old ICR mice^[1]
Dosage:	100 mg/kg
Administration:	P.o.
Result:	Sgnificantly reduced the blood glucose AUC after 2 h (AUC_0-2h) of administration. Similarly, plasma insulin AUC_0-2h was significantly higher in the mice.

IC 50

GPR119; TRPA1

References

[1]. shigeru yoshida, hirotsugu tanaka, hiroyuki oshima, et al. as1907417, a novel gpr119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. biochemical and biophysical research communications, 2010, 400: 745-751.
[2]. shigeru yoshida, takahide ohishi, tetsuo matsui, et al. identification of a novel gpr119 agonist, as1269574, with in vitro and in vivo glucose-stimulated insulin secretion. biochemical and biophysical research communications, 2010, 400: 437-441.

AS 1269574 Preparation Products And Raw materials

Raw materials

Preparation Products

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AS 1269574 Suppliers

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330981-72-1, AS 1269574Related Search:

AS 1269574

2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol

2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol

AS-1269574 (AS1269574)

AS126957

2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol

Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-

TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574

AS1269574, 10 mM in DMSO

GPR119 Agonist, AS1269574

AS1269574 ，E0347

330981-72-1

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals