ChemicalBook > CAS DataBase List > JNJ 5207852 dihydrochloride

JNJ 5207852 dihydrochloride

Product Name: JNJ 5207852 dihydrochloride
CAS No.: 398473-34-2
Chemical Name: JNJ 5207852 dihydrochloride
Synonyms: JNJ 5207852;JNJ-5207852, 10 mM in DMSO;JNJ 5207852 dihydrochloride;1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine;1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE;Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-;1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride;sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit
CBNumber: CB82535676
Molecular Formula: C20H32N2O
Formula Weight: 316.48
MOL File: 398473-34-2.mol

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JNJ 5207852 dihydrochloride Property

Boiling point:: 443.4±30.0 °C(Predicted)
Density: 1.032±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic)
form: Powder
pka: 9.70±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11998
Product name: JNJ-5207852
Purity: ≥98%
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 11998
Product name: JNJ-5207852
Purity: ≥98%
Packaging: 10mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 11998
Product name: JNJ-5207852
Purity: ≥98%
Packaging: 50mg
Price: $700
Updated: 2024/03/01

Tocris

Product number: 4020
Product name: JNJ5207852dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $772
Updated: 2021/12/16

Tocris

Product number: 4020
Product name: JNJ5207852dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

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JNJ 5207852 dihydrochloride Chemical Properties,Usage,Production

Uses

JNJ 5207852 is a Histamine H3 Receptor antagonist, used in the treatment of obesity.

in vivo

JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H₃ receptor knockout mice. The wake promoting effects of this H₃ receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels^[1].

Animal Model:	Male, Sprague-Dawley rats weighing 282-334 g^[1].
Dosage:	3, 10, 30 mg/kg.
Administration:	S.C.
Result:	Iincreased time spent awake and decreased REM sleep and slow-wave sleep.

IC 50

H₃ receptor: 8.9 (pKi, for rat); H₃ receptor: 9.24 (pKi, for human)

JNJ 5207852 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from JNJ 5207852 dihydrochloride manufacturers

Career Henan Chemical Co

Product: 1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine 398473-34-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

398473-34-2, JNJ 5207852 dihydrochlorideRelated Search:

JNJ 5207852 dihydrochloride

JNJ 5207852

Piperidine, 1-[3-[4-(1-piperidinylmethyl)phenoxy]propyl]-

1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride

1-{3-[4-(PIPERIDIN-1-YLMETHYL)PHENOXY]PROPYL}PIPERIDINE

1-(4-(3-piperidin-1-ylpropoxy)benzyl)piperidine

sleep,low,JNJ5207852,Histamine Receptor,JNJ-5207852,JNJ 5207852,Inhibitor,REM,toxicity,inhibit

JNJ-5207852, 10 mM in DMSO

398473-34-2

98473-34-2

C20H32N2O2HCl

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