ChemicalBook > CAS DataBase List > LY 266097 hydrochloride

LY 266097 hydrochloride

Product Name
LY 266097 hydrochloride
CAS No.
172895-39-5
Chemical Name
LY 266097 hydrochloride
Synonyms
LY266097;LY 266097;LY 266097 hydrochloride;LY266097 >=98% (HPLC), powder;LY266097 hydrochloride, 10 mM in DMSO;LY-266097 hydrochloride,LY266097 hydrochloride;1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
CBNumber
CB82535681
Molecular Formula
C21H24Cl2N2O2
Formula Weight
407.34
MOL File
172895-39-5.mol
More
Less

LY 266097 hydrochloride Property

storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
white to tan
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L6670
Product name
LY266097
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$130.15
Updated
2025/07/31
Sigma-Aldrich
Product number
L6670
Product name
LY266097
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$548
Updated
2025/07/31
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
11935
Product name
LY266097 (hydrochloride)
Packaging
5mg
Price
$139
Updated
2024/03/01
More
Less

LY 266097 hydrochloride Chemical Properties,Usage,Production

Uses

LY 266097 Hydrochloride is a potent and selective serotonin 2B (5HT2B) contractile receptor.

Biological Activity

LY266097 is a selective 5HT-2B antagonist with a pKI of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity for 5-HT2B than the human 5-HT2C and 5-HT2A.

in vivo

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) [1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity[1].

Animal Model:Male Sprague-Dawley rats weighing 250-350?g[1]
Dosage:0.6?mg/kg
Administration:Administered i.p. alone or concomitantly with Escitalopram (2?mg/kg) for 2 days
Result:Short-term administration (0.6?mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.

IC 50

5-HT2B Receptor: 9.8 (pKi); 5-HT2A Receptor: 7.7 (pKi); 5-HT2C Receptor: 7.6 (pKi)

storage

Store at +4°C

LY 266097 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LY 266097 hydrochloride Suppliers

China 21 United Kingdom 1 United States 7 Global 29
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Guangzhou Taozhu Biotechnology Co., Ltd
Tel
4008200310
Country
CHINA
ProdList
111
Advantage
58
Foshan Minghua Biotechnology Co., Ltd.
Tel
18312287787
Country
CHINA
ProdList
196
Advantage
58
Aoki Biotechnology (Shenzhen) Co., Ltd.
Tel
18566777408
Country
CHINA
ProdList
156
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

172895-39-5, LY 266097 hydrochlorideRelated Search:


  • LY 266097 hydrochloride
  • 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
  • LY 266097
  • LY266097
  • LY266097 >=98% (HPLC), powder
  • LY-266097 hydrochloride,LY266097 hydrochloride
  • LY266097 hydrochloride, 10 mM in DMSO
  • 172895-39-5
  • C21H23ClN2O2HCl