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TCS JNK 6o

Product Name
TCS JNK 6o
CAS No.
894804-07-0
Chemical Name
TCS JNK 6o
Synonyms
TCS JNK 6o;JNK Inhibitor VIII;TCS JNK 6o(JNK Inhibitor VIII);JNK INHIBITOR VIII (TCS JNK 6O);JNK,inhibit,Inhibitor,JNK Inhibitor VIII;JNK inhibitor VIII - JNK inhibitor compound 6o;N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide;Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-;N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
CBNumber
CB82535702
Molecular Formula
C18H20N4O4
Formula Weight
356.38
MOL File
894804-07-0.mol
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TCS JNK 6o Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15946
Product name
JNK Inhibitor VIII
Purity
≥98%
Packaging
5mg
Price
$101
Updated
2024/03/01
Cayman Chemical
Product number
15946
Product name
JNK Inhibitor VIII
Purity
≥98%
Packaging
1mg
Price
$55
Updated
2023/06/20
Cayman Chemical
Product number
15946
Product name
JNK Inhibitor VIII
Purity
≥98%
Packaging
10mg
Price
$192
Updated
2024/03/01
Tocris
Product number
3222
Product name
TCSJNK6o
Purity
≥98%(HPLC)
Packaging
10
Price
$233
Updated
2021/12/16
Tocris
Product number
3222
Product name
TCSJNK6o
Purity
≥98%(HPLC)
Packaging
50
Price
$990
Updated
2021/12/16
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TCS JNK 6o Chemical Properties,Usage,Production

Description

c-Jun amino terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. They have been implicated in neurodegeneration, rheumatoid arthritis, inflammation, cancer, and diabetes. JNK1 and JNK2 are widely expressed throughout the body whereas JNK3 is predominantly distributed in the brain. JNK Inhibitor VIII is an aminopyridine compound that inhibits JNK1, JNK2, and JNK3 with Ki values of 2, 4, and 52 nM, respectively. It has been reported to inhibit the phosphorylation of the JNK substrate c-Jun in HepG2 cells (EC50 = 920 nM) without affecting the expression of IL-6, IL-8, or COX-2.

Uses

JNK Inhibitor VIII is an inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release.

in vitro

cs jnk 6o, in a dose-dependent manner, inhibits phosphorylation of c-jun (ec50 = 920 nm) and prevents collagen-induced platelet aggregation. at low collagen concentrations (0.2 and 0.5 μg/ml), platelet aggregation was totally or partially impaired by 10 μm cs jnk 6o, whereas at a high collagen concentration (5 μg/ml), tcs jnk 6o had no effect [2].

in vivo

. pharmacokinetic profiles were studied for tcs jnk 6o in sprague-dawley rats. tcs jnk 6o showed a short half-life of about 1 hour, with barely measurable bioavailability and rapid clearance. microsomal incubation studies revealed that the oxidative metabolism of tcs jnk 6o was very rapid [1]

IC 50

45 nm for jnk1 and 160 nm for jnk2 [1]

storage

Store at +4°C

References

[1] szczepankiewicz bg1, kosogof c, nelson lt, liu g, liu b, zhao h, serby md, xin z, liu m, gum rj, haasch dl, wang s, clampit je, johnson ef, lubben th, stashko ma, olejniczak et, sun c, dorwin sa, haskins k, abad-zapatero c, fry eh, hutchins cw, sham hl, rondinone cm, trevillyan jm. aminopyridine-based c-jun n-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. j med chem. 2006 jun 15;49(12):3563-80.
[2] kauskot a, adam f, mazharian a, ajzenberg n, berrou e, bonnefoy a, rosa jp, hoylaerts mf, bryckaert m. involvement of the mitogen-activated protein kinase c-jun nh2-terminal kinase 1 in thrombus formation. j biol chem. 2007 nov 2;282(44):31990-9.

TCS JNK 6o Preparation Products And Raw materials

Raw materials

Preparation Products

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TCS JNK 6o Suppliers

China 37 United Kingdom 1 United States 10 Global 48
BOC Sciences
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894804-07-0, TCS JNK 6oRelated Search:

Jnk Inhibitor Viii

  • TCS JNK 6o
  • JNK Inhibitor VIII
  • N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
  • JNK INHIBITOR VIII (TCS JNK 6O)
  • N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
  • JNK inhibitor VIII - JNK inhibitor compound 6o
  • Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-
  • TCS JNK 6o(JNK Inhibitor VIII)
  • JNK,inhibit,Inhibitor,JNK Inhibitor VIII
  • 894804-07-0