SB 290157 trifluoroacetate salt

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SB 290157 trifluoroacetate salt

Product Name: SB 290157 trifluoroacetate salt
CAS No.: 1140525-25-2
Chemical Name: SB 290157 trifluoroacetate salt
Synonyms: SB290157 (trifluoroacetate);SB 290157 trifluoroacetate salt;SB290157 trifluoroacetate, 10 mM in DMSO;SB 290157 - CAS 1140525-25-2 - Calbiochem;SB 290157 TRIFLUOROACETATE; SB-290157 TRIFLUOROACETATE;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine, 2,2,2-trifluor;N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine (trifluoroacetate);(2-(2,2-Diphenylethoxy)acetyl)-L-arginine 2,2,2-trifluoroacetate;(2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid;(2S)-5-(Diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoicacid,2,2,2-trifluoroaceticacid
CBNumber: CB82537362
Molecular Formula: C24H29F3N4O6
Formula Weight: 526.51
MOL File: 1140525-25-2.mol

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SB 290157 trifluoroacetate salt Property

Melting point:: >43°C (dec.)
storage temp.: -20°C
solubility: Ethanol (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form: powder
color: white to beige
optical activity: [α]/D +1.5 to +5°, c = 1.0 in DMSO
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1192
Product name: SB290157 trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $103
Updated: 2024/03/01

Sigma-Aldrich

Product number: 559410
Product name: SB 290157 - CAS 1140525-25-2 - Calbiochem
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 15783
Product name: SB 290157 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 15783
Product name: SB 290157 (trifluoroacetate salt)
Purity: ≥95%
Packaging: 5mg
Price: $87
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1192
Product name: SB290157 trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $403
Updated: 2024/03/01

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SB 290157 trifluoroacetate salt Chemical Properties,Usage,Production

Uses

SB 290157 Trifluoroacetate Salt is a selective, high affinity, competitive antagonist of anaphylatoxin C3a receptor.

General Description

A non-peptide with anti-inflammatory properties that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (C3aR; IC₅₀ = 200 nM). Does not antagonize C5aR or other chemotactic G-protein coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca²⁺ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC₅₀ = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from guinea pig platelets (IC₅₀ = 30 nM).

Biological Activity

sb 290157 is a c3ar antagonist.the anaphylatoxin c3a, a potent chemotactic peptide and inflammatory mediator, binds to and activates a g-protein-coupled receptor. molecular cloning of the c3ar has facilitated the identification of the non-peptide c3ar antagonists.

Biochem/physiol Actions

Target IC50: 200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR

in vitro

sb 290157 was a competitive antagonist of 125i-c3a and binding to rat basophilic leukemia (rbl)-2h3 cells expressing the human c3ar , with an ic50 of 200 nm. sb 290157 could also block the c3a-induced c3ar internalization concentration-dependently and c3a-induced ca21 mobilization in rbl-c3ar cells and human neutrophils. sb 290157 was founf to be selective for the c3ar in that it did not antagonize the c5ar or six other chemotactic g protein-coupled receptors. in addition, sb 290157 could also inhibit c3a induced ca21 mobilization of rbl-2h3 cells expressing the mouse and guinea pig c3ars [1].

in vivo

in animal models, sb 290157 was able to inhibit neutrophil recruitment in a guinea pig lps-induced airway neutrophilia model and decrease paw edema in a rat adjuvant-induced arthritis model [1].

IC 50

200 nm

storage

Desiccate at RT

References

[1] r. s. ames, d. lee, j. j. foley, et al. identification of a selective nonpeptide antagonist of the anaphylatoxin c3a receptor that demonstrates antiinflammatory activity in animal models. journal of immunology 166(10), 6341-6348 (2001).

SB 290157 trifluoroacetate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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1140525-25-2, SB 290157 trifluoroacetate saltRelated Search:

SB 290157 trifluoroacetate salt

SB290157 (trifluoroacetate)

SB 290157 TRIFLUOROACETATE; SB-290157 TRIFLUOROACETATE

SB 290157 - CAS 1140525-25-2 - Calbiochem

(2S)-5-(diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoic acid

N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine, 2,2,2-trifluor

N2-(2-(2,2-diphenylethoxy)acetyl)-L-arginine (trifluoroacetate)

SB290157,SB-290157 trifluoroacetate,Inhibitor,inhibit,SB 290157,Complement System,SB-290157,SB290157 trifluoroacetate

(2-(2,2-Diphenylethoxy)acetyl)-L-arginine 2,2,2-trifluoroacetate

(2S)-5-(Diaminomethylideneamino)-2-[[2-(2,2-diphenylethoxy)acetyl]amino]pentanoicacid,2,2,2-trifluoroaceticacid

SB290157 trifluoroacetate, 10 mM in DMSO

1140525-25-2

C22H28N4O4CF3COOH