CID 2745687

Product Name: CID 2745687
CAS No.: 264233-05-8
Chemical Name: CID 2745687
Synonyms: CID 2745687;Methyl 1-(2,4-Difluoro-phenyl)-5-((4-tert-butyl-thioseMicarbazono)Methyl)-1H-pyrazole-4-carboxylate;methyl 5-[(E)-(tert-butylcarbamothioylhydrazono)methyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxylate;GPCR,CID-2745687,CID2745687,G Protein-coupled Receptors,inhibit,Inhibitor,CID 2745687,Arrestin,GPR35 antagonist;1H-Pyrazole-4-carboxylic acid, 1-(2,4-difluorophenyl)-5-[[2-[[(1,1-dimethylethyl)amino]thioxomethyl]hydrazinylidene]methyl]-, methyl ester
CBNumber: CB82538273
Molecular Formula: C17H19F2N5O2S
Formula Weight: 395.43
MOL File: 264233-05-8.mol

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CID 2745687 Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 12046
Product name: CID-2745687
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 12046
Product name: CID-2745687
Purity: ≥95%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 12046
Product name: CID-2745687
Purity: ≥95%
Packaging: 25mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 12046
Product name: CID-2745687
Purity: ≥95%
Packaging: 50mg
Price: $593
Updated: 2024/03/01

Tocris

Product number: 4293
Product name: CID2745687
Purity: ≥98%(HPLC)
Packaging: 50
Price: $824
Updated: 2021/12/16

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CID 2745687 Chemical Properties,Usage,Production

Description

GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid). It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract. GPR35 is overexpressed in gastric cancer cells. CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a K_i value of 12.8 nM. It less potently blocks activation of GPR35 by zaprinast (IC₅₀ = 160 nM). It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC₅₀ = 9.08 μM).

Uses

CID 2745687 is used as a GPR35 antagonist, with potential application towards immune or gastrointestinal system regulation.

Definition

ChEBI: 5-[[[(tert-butylamino)-sulfanylidenemethyl]hydrazinylidene]methyl]-1-(2,4-difluorophenyl)-4-pyrazolecarboxylic acid methyl ester is a ring assembly and a member of pyrazoles.

in vitro

previous study indicated that both cid-2745687 and ml-145 could competitively inhibit the effects of cromolyn disodium and zaprinast (two agonists sharing an overlapping binding site) on human gpr35. in contrast, though ml-145 antagonized the effects of pamoate competitively, cid-2745687 showed a noncompetitive fashion. additionally, neither ml-145 nor cid-2745687 was able to antagonize the agonist effects at rodent ortholog of gpr35 [1].

in vivo

to test whether gpr35 contributes to the metabolic effect of zaprinast, the retina from cngb1/ mice was preincubated with a gpr35 antagonist, cid-2745687, followed by an additional zaprinast treatment. results showed that cid-2745687 did not block the effect of zaprinast on glutamate and aspartate. moreover, pamoic acid, the gpr35 agonist, did not change aspartate or glutamate levels [1].

storage

Store at -20°C

References

[1] jenkins l,harries n,lappin je,mackenzie ae,neetoo-isseljee z,southern c,mciver eg,nicklin sa,taylor dl,milligan g. antagonists of gpr35 display high species ortholog selectivity and varying modes of action. j pharmacol exp ther.2012 dec;343(3):683-95.
[2] du j,cleghorn wm,contreras l,lindsay k,rountree am,chertov ao,turner sj,sahaboglu a,linton j,sadilek m,satrústegui j,sweet ir,paquet-durand f,hurley jb. inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina. j biol chem.2013 dec 13;288(50):36129-40.

CID 2745687 Preparation Products And Raw materials

Raw materials

Preparation Products

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CID 2745687 Suppliers

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264233-05-8, CID 2745687Related Search:

CID 2745687

Methyl 1-(2,4-Difluoro-phenyl)-5-((4-tert-butyl-thioseMicarbazono)Methyl)-1H-pyrazole-4-carboxylate

methyl 5-[(E)-(tert-butylcarbamothioylhydrazono)methyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxylate

1H-Pyrazole-4-carboxylic acid, 1-(2,4-difluorophenyl)-5-[[2-[[(1,1-dimethylethyl)amino]thioxomethyl]hydrazinylidene]methyl]-, methyl ester

GPCR,CID-2745687,CID2745687,G Protein-coupled Receptors,inhibit,Inhibitor,CID 2745687,Arrestin,GPR35 antagonist

264233-05-8

C17H19F2N5O2S

Aromatics, Diagnostic and Labeling Agents, Pharmaceuticals, Intermediates & Fine Chemicals