ChemicalBook > CAS DataBase List > Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE

Product Name
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
CAS No.
114014-15-2
Chemical Name
Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
Synonyms
Z-FY(T-BU)-DMK;Z-Phe-Tyr(tBu)-CHN2;Cbz-Phe-Tyr(O-t-Bu)-CHN2;CATHEPSIN L INHIBITOR III;Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE;CBZ-PHE-TYR(O-T-BU)-CHN2;Z-PHE-TYR(TBU)-CHN2
CBNumber
CB8254517
Molecular Formula
C31H34N4O5
Formula Weight
542.63
MOL File
Mol file
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Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Property

storage temp. 
-15°C
solubility 
Ethyl Acetate: 10 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
219427
Product name
Cathepsin L Inhibitor III
Purity
The Cathepsin L Inhibitor III controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Packaging
5MG
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
27877
Product name
Z-Phe-Tyr(tBu)-diazomethylketone
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
27877
Product name
Z-Phe-Tyr(tBu)-diazomethylketone
Packaging
25mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
27877
Product name
Z-Phe-Tyr(tBu)-diazomethylketone
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
27877
Product name
Z-Phe-Tyr(tBu)-diazomethylketone
Packaging
10mg
Price
$257
Updated
2024/03/01
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Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Chemical Properties,Usage,Production

Uses

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

Biological Activity

Cell permeable: yes', 'Primary Target
Cathepsin L', 'Product does not compete with ATP.', 'Reversible: no

IC 50

cathepsin L

References

[1] Ebert DH, et al. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells. J Biol Chem. 2002 Jul 5;277(27):24609-17. DOI:10.1074/jbc.M201107200
[2] Perez-Bermejo JA, et al. SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19. Sci Transl Med. 2021 Apr 21;13(590):eabf7872. DOI:10.1126/scitranslmed.abf7872

Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE Suppliers

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114014-15-2, Z-PHE-TYR(TBU)-DIAZOMETHYLKETONERelated Search:


  • CATHEPSIN L INHIBITOR III
  • Z-FY(T-BU)-DMK
  • Z-PHE-TYR(TBU)-DIAZOMETHYLKETONE
  • Cbz-Phe-Tyr(O-t-Bu)-CHN2
  • CBZ-PHE-TYR(O-T-BU)-CHN2;Z-PHE-TYR(TBU)-CHN2
  • Z-Phe-Tyr(tBu)-CHN2
  • 114014-15-2