Plerixafor
- Product Name
- Plerixafor
- CAS No.
- 1246819-87-3
- Chemical Name
- Plerixafor
- Synonyms
- Plerixafor-d4;[2H4]-Plerixafor;Paclobutrazol Impurity 6
- CBNumber
- CB82545583
- Molecular Formula
- C28H54N8
- Formula Weight
- 502.78196
- MOL File
- 1246819-87-3.mol
Plerixafor Property
- Melting point:
- 100-102°C
- storage temp.
- Hygroscopic, Refrigerator, Under Inert Atmosphere
- solubility
- DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Light Yellow
- Stability:
- Very Hygroscopic
N-Bromosuccinimide Price
- Product number
- 26490
- Product name
- Plerixafor-d4
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 26490
- Product name
- Plerixafor-d4
- Packaging
- 1mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- P580502
- Product name
- Plerixafor-d4
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 019845
- Product name
- Plerixafor-d4
- Packaging
- 2.5mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- P580502
- Product name
- Plerixafor-d4
- Packaging
- 10mg
- Price
- $1190
- Updated
- 2021/12/16
Plerixafor Chemical Properties,Usage,Production
Description
Plerixafor-d4 is intended for use as an internal standard for the quantification of plerixafor by GC- or LC-MS. Plerixafor is a partial antagonist of chemokine receptor 4 (CXCR4) with IC50 values ranging from 0.02 to 0.13 μg/ml for inhibiting calcium flux in peripheral blood mononuclear cells (PBMCs), various types of T cells, and mouse lymphocytic leukemia cells. It is selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 μg/ml). Plerixafor decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 μg/ml). It rapidly mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation alone and, with a synergistic effect, when used in combination with G-CSF. Plerixafor also increases T cell trafficking in mouse blood, spleen, and central nervous system. Plerixafor (1.25 mg/kg twice per day) decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis.
Chemical Properties
Off-White Solid
Uses
Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).
Uses
Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transpl antation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).
Plerixafor Preparation Products And Raw materials
Raw materials
Preparation Products
Plerixafor Suppliers
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