Benzene, 1-ethynyl-4-iodo-
- Product Name
- Benzene, 1-ethynyl-4-iodo-
- CAS No.
- 766-99-4
- Chemical Name
- Benzene, 1-ethynyl-4-iodo-
- Synonyms
- 4-iodophenylacetylene;1-Ethynyl-4-iodobenzene;Benzene, 1-ethynyl-4-iodo-
- CBNumber
- CB82548519
- Molecular Formula
- C8H5I
- Formula Weight
- 228.03
- MOL File
- 766-99-4.mol
Benzene, 1-ethynyl-4-iodo- Property
- Melting point:
- 68-69 °C
- Boiling point:
- 221.2±23.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 1951AC
- Product name
- 1-Ethynyl-4-iodobenzene
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- AS101747
- Product name
- 1-Ethynyl-4-iodo-benzene
- Purity
- 95%
- Packaging
- 1g
- Price
- $471
- Updated
- 2021/12/16
- Product number
- HCH0362335
- Product name
- 1-ETHYNYL-4-IODOBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.8
- Updated
- 2021/12/16
- Product number
- AS101747
- Product name
- 1-Ethynyl-4-iodo-benzene
- Purity
- 95%
- Packaging
- 5G
- Price
- $1458
- Updated
- 2021/12/16
- Product number
- CD12034209
- Product name
- 1-Ethynyl-4-iodobenzene
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1485
- Updated
- 2021/12/16
Benzene, 1-ethynyl-4-iodo- Chemical Properties,Usage,Production
Uses
1-Ethynyl-4-iodobenzene is used to synthesize quinoline derivatives.
Synthesis
134856-58-9
766-99-4
General procedure for the synthesis of 4-iodophenylacetylene from (4-iodophenylethynyl)trimethylsilane: To a solution of (4-iodophenylethynyl)trimethylsilane (5) (2.07 g, 6.23 mmol) in methanol (40 mL) was added K2CO3 (8.0 g, 57.9 mmol), and the reaction mixture was stirred for 48 hours. Upon completion of the reaction, the volatiles were removed under vacuum and the residue was partitioned between ethyl acetate and H2O. The organic and aqueous layers were separated and the aqueous phase was re-extracted with ethyl acetate (2 x 20 mL). The organic layers were combined, washed sequentially with H2O and brine, dried with Na2SO4 and filtered. The solvent was removed in vacuum and the residue was crystallized from hexane at -20 °C (in two batches) to afford 1-ethynyl-4-iodobenzene (6) as a colorless solid (0.92 g, 64% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.66 (app d, J=8.6 Hz, 2H), 7.20 (app d, J=8.5 Hz, 2H), 1.54 (s, 1H).
References
[1] Chemistry - A European Journal, 2013, vol. 19, # 48, p. 16240 - 16247
[2] Synthetic Communications, 2003, vol. 33, # 14, p. 2447 - 2461
[3] Patent: WO2008/144380, 2008, A1. Location in patent: Page/Page column 27-28
[4] Journal of the American Chemical Society, 2013, vol. 135, # 4, p. 1264 - 1267
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 49, p. 15649 - 15653
Benzene, 1-ethynyl-4-iodo- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzene, 1-ethynyl-4-iodo- manufacturers
- Product
- Benzene, 1-ethynyl-4-iodo 766-99-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12