3,6-Dichloropyridazine-4-carbonitrile
- Product Name
- 3,6-Dichloropyridazine-4-carbonitrile
- CAS No.
- 35857-93-3
- Chemical Name
- 3,6-Dichloropyridazine-4-carbonitrile
- Synonyms
- 3,6-Dichloropyridazine-4-carbonitrile;3,6-Dichloro-4-pyridazinecarbonitrile;4-Pyridazinecarbonitrile, 3,6-dichloro-
- CBNumber
- CB82549617
- Molecular Formula
- C5HCl2N3
- Formula Weight
- 173.99
- MOL File
- 35857-93-3.mol
3,6-Dichloropyridazine-4-carbonitrile Property
- Melting point:
- 105-106 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 360.8±37.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -4.95±0.10(Predicted)
- Appearance
- White to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D437133
- Product name
- 3,6-Dichloropyridazine-4-carbonitrile
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FD143812
- Product name
- 3,6-Dichloropyridazine-4-carbonitrile
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD143812
- Product name
- 3,6-Dichloropyridazine-4-carbonitrile
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 3H37-5-2D
- Product name
- 3,6-Dichloropyridazine-4-carbonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- FD143812
- Product name
- 3,6-Dichloropyridazine-4-carbonitrile
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
3,6-Dichloropyridazine-4-carbonitrile Chemical Properties,Usage,Production
Synthesis
27427-66-3
35857-93-3
3,6-Dichloropyridazine-4-carboxamide (5.7 g, 29.69 mmol, 1.00 eq.) was mixed with phosphorus trichloride (50 mL) and heated to reflux for 1 hour. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove excess phosphorous trichloride. The concentrated residue was dissolved in dichloromethane and washed sequentially with water and saturated saline to remove water-soluble impurities. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of ethyl acetate and petroleum ether (1:5, v/v). The final product was 3,6-dichloropyridazine-4-carbonitrile (5.1 g, 99% yield) as a light yellow solid.
References
[1] Patent: WO2015/25025, 2015, A1. Location in patent: Page/Page column 408
[2] Patent: WO2017/133665, 2017, A1. Location in patent: Page/Page column 40
3,6-Dichloropyridazine-4-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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