Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate
- Product Name
- Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate
- CAS No.
- 65269-18-3
- Chemical Name
- Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate
- Synonyms
- Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate;4-Chloro-2-methoxypyrimidine-5-carboxylic acid ethyl ester;5-Pyrimidinecarboxylic acid, 4-chloro-2-methoxy-, ethyl ester
- CBNumber
- CB82549743
- Molecular Formula
- C8H9ClN2O3
- Formula Weight
- 216.62
- MOL File
- 65269-18-3.mol
Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate Property
- Boiling point:
- 327.8±45.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- -20°C, sealed storage, away from moisture
- pka
- -1.85±0.29(Predicted)
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E903578
- Product name
- Ethyl4-chloro-2-methoxypyrimidine-5-carboxylate
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- E903578
- Product name
- Ethyl4-chloro-2-methoxypyrimidine-5-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-W022686
- Product name
- Ethyl4-chloro-2-methoxypyrimidine-5-carboxylate
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-W022686
- Product name
- Ethyl4-chloro-2-methoxypyrimidine-5-carboxylate
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $62
- Updated
- 2021/12/16
- Product number
- CS-W022686
- Product name
- Ethyl4-chloro-2-methoxypyrimidine-5-carboxylate
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $387
- Updated
- 2021/12/16
Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate Chemical Properties,Usage,Production
Synthesis
65407-49-0
65269-18-3
Stage B - Synthesis of 4-chloro-5-ethoxycarbonyl-2-methoxypyrimidine: 99 g (0.5 mol) of 5-ethoxycarbonyl-4-hydroxy-2-methoxypyrimidine was suspended in 200 cm3 dimethylformamide (D.M.F.). Under stirring, 89 g (0.75 mol) of thionyl chloride was added slowly over about 5 minutes. The mixture was heated until the solid was completely dissolved. The resulting homogeneous solution was continued to be stirred at room temperature for 30 minutes. Under stirring, the reaction mixture was slowly poured into a mixture consisting of 250 g of ice and 1 L of water. After continued stirring for 15 min, the reaction product was extracted with benzene (2 x 400 cm3). The organic phases were combined and washed sequentially with dilute sodium bicarbonate solution and water, followed by drying with anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to give 101.6 g of 4-chloro-5-ethoxycarbonyl-2-methoxypyrimidine in oil form in 94% yield. The product was purified by vacuum distillation with a boiling point of 120 °C (0.9 mmHg), and the distillate was crystallized after cooling with a melting point of 26-28 °C. Elemental analysis (C8H9ClN2O3, molecular weight 216.5): calculated values: C, 44.34; H, 4.16; N, 12.93. measured values: C, 44.18; H, 4.33; N, 12.88.
References
[1] Patent: US4125720, 1978, A
Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate manufacturers
- Product
- Ethyl 4-chloro-2-MethoxypyriMidine-5-carboxylate 65269-18-3
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-12