1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1000801-75-1
Chemical Name: 1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-Cyclopropylmethyl-1H-pyrazole-4-boronic acid picol ester;1-(Cyclopropylmethyl)pyrazole-4-boronic Acid Pinacol Ester;1-CyclopropylMethyl-1H-pyrazole-4-boronic acid, pinacol ester;1-Cyclopropylmethyl-1H-pyrazole-4-boronic acid, pinacol ester 97%;1-(cyclopropylmethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1H-Pyrazole, 1-(cyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB82549763
Molecular Formula: C13H21BN2O2
Formula Weight: 248.13
MOL File: 1000801-75-1.mol

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1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 362.8±15.0 °C(Predicted)
Density: 1.14
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 2.07±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C991618
Product name: 1-Cyclopropylmethyl-1H-pyrazole-4-boronicacid,pinacolester
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 093569
Product name: 1-(Cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 97%
Packaging: 100mg
Price: $62.5
Updated: 2021/12/16

Apolloscientific

Product number: OR360142
Product name: 1-Cyclopropylmethyl-1H-pyrazole-4-boronic acid, pinacol ester
Purity: 97%
Packaging: 250mg
Price: $122
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-HR
Product name: 1-Cyclopropylmethyl-1H-pyrazole-4-boronic acid, pinacol ester
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Apolloscientific

Product number: OR360142
Product name: 1-Cyclopropylmethyl-1H-pyrazole-4-boronic acid, pinacol ester
Purity: 97%
Packaging: 1g
Price: $304
Updated: 2021/12/16

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1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Synthesis

269410-08-4

7051-34-5

1000801-75-1

General procedure for the synthesis of 1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole from 4-pyrazolylboronic acid pinacol ester and bromomethylcyclopropane: Bromomethylcyclopropane (0.95 mg, 6.70 mmol, 0.70 mL, 95%) was added to a solution containing 4-(4,4,5, 5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole at 0°C. 5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (1.00 g, 5.15 mmol) and cesium carbonate (3.49 mg, 10.72 mmol) in a mixture of anhydrous N,N-dimethylformamide (20 mL). After stirring for 30 min, the ice water bath was removed. The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction mixture was diluted with ethyl acetate (150 mL) and washed with brine (3 x 100 mL). The organic layer was dried with sodium sulfate and concentrated in vacuum to afford 1.30 g (4.38 mmol, 85% yield) of the target compound 1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.GC-MS (Method L9): rt = 4.35 min; m/z = 247. 1H NMR (300 MHz, CDCl3, Method M2) δ 7.81 (s, 1H), 7.79 (s, 1H), 3.99 (d, J = 7.1 Hz, 2H), 1.32 (s, 12H), 1.27 (m, 1H), 0.71-0.58 (m, 2H), 0.41-0.33 (m, 2H).

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 10, p. 4196 - 4212
[2] Patent: WO2017/178416, 2017, A1. Location in patent: Page/Page column 114; 115
[3] Patent: WO2014/210354, 2014, A1. Location in patent: Page/Page column 47; 48
[4] Patent: WO2017/102091, 2017, A1. Location in patent: Page/Page column 435
[5] Patent: WO2017/207534, 2017, A1. Location in patent: Page/Page column 180

1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

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View Lastest Price from 1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Career Henan Chemical Co

Product: 1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1000801-75-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2019-12-25

1000801-75-1, 1-(CyclopropylMethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

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1000801-75-1