tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate
- Product Name
- tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate
- CAS No.
- 821767-61-7
- Chemical Name
- tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate
- Synonyms
- 1-BOC-4-FORMYLPYRAZOLE;tert-butyl 4-forMyl-1H-py...;N-BOC-pyrazole-4-carbaldehyde;1-Boc-pyrazole-4-carbaldehyde;1-boc-pyrazole-4-formaldehyde;tert-butyl 4-formylpyrazole-1-carboxylate;tert-Butyl 4-formyl-1H-pyrazol-1-carboxylate;tert-butyl 3-forMyl-1H-pyrazole-1-carboxylate;tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate;4-Formyl-pyrazole-1-carboxylic acid tert-butylester
- CBNumber
- CB82549965
- Molecular Formula
- C9H12N2O3
- Formula Weight
- 196.2
- MOL File
- 821767-61-7.mol
tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate Property
- Boiling point:
- 302.2±34.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.13±0.12(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B814373
- Product name
- tert-Butyl4-Formyl-1H-pyrazole-1-carboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B814373
- Product name
- tert-Butyl4-Formyl-1H-pyrazole-1-carboxylate
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 2713AC
- Product name
- tert-Butyl4-formyl-1H-pyrazole-1-carboxylate
- Packaging
- 1g
- Price
- $223
- Updated
- 2021/12/16
- Product number
- OR55293
- Product name
- tert-Butyl4-formyl-1H-pyrazole-1-carboxylate
- Packaging
- 1g
- Price
- $261
- Updated
- 2021/12/16
- Product number
- 2713AC
- Product name
- tert-Butyl4-formyl-1H-pyrazole-1-carboxylate
- Packaging
- 100mg
- Price
- $111
- Updated
- 2021/12/16
tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate Chemical Properties,Usage,Production
Synthesis
24424-99-5
35344-95-7
821767-61-7
Step A: Di-tert-butyl dicarbonate (Boc2O, 2183 mg, 10.0 mmol) was slowly added to a stirring solution of 1H-pyrazole-4-carboxaldehyde (961 mg, 10.0 mmol) acetonitrile (30 mL) at room temperature, followed by the addition of 4-dimethylaminopyridine (DMAP, 61.1 mg, 0.500 mmol) as a catalyst. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was extracted by partitioning with ethyl acetate (30 mL) and water (30 mL). The organic phase was separated and washed sequentially with 0.5 N HCl (30 mL) and saturated saline (30 mL). The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated to give the crude product. The crude product was purified by chromatography on a Biotage 40M silica gel column using hexane/ethyl acetate (4:1, v/v) as eluent. Fractions containing the target product were collected, combined and concentrated under reduced pressure to afford tert-butyl 4-formyl-1H-pyrazole-1-carboxylate (1.4 g, 71% yield) as a solid.
References
[1] Patent: WO2005/813, 2005, A1. Location in patent: Page 36
[2] Patent: WO2013/130976, 2013, A1. Location in patent: Paragraph 00383
tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate manufacturers
- Product
- tert-Butyl 4-forMyl-1H-pyrazole-1-carboxylate 821767-61-7
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07