Methyl 6-bromo-5-fluoropyridine-2-carboxylate
- Product Name
- Methyl 6-bromo-5-fluoropyridine-2-carboxylate
- CAS No.
- 1210419-26-3
- Chemical Name
- Methyl 6-bromo-5-fluoropyridine-2-carboxylate
- Synonyms
- uoropicoL;6-bromo-5-fL;methyl 6-bromo-5-fluoropicolinat;Methyl 6-bromo-5-fluoropicolinate;N'-(3,4-dichlorophenyl)ethane-1,6-diamine;Methyl 6-bromo-5-fluoropyridine-2-carboxylate;6-Bromo-5-fluoro-pyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid, 6-bromo-5-fluoro-, methyl ester;Methyl 6-bromo-5-fluoropicolinate, 2-Bromo-3-fluoro-6-(methoxycarbonyl)pyridine
- CBNumber
- CB82553052
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 1210419-26-3.mol
Methyl 6-bromo-5-fluoropyridine-2-carboxylate Property
- Boiling point:
- 275.5±35.0 °C(Predicted)
- Density
- 1.660±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -3.45±0.10(Predicted)
- form
- solid
- color
- white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M296360
- Product name
- Methyl6-bromo-5-fluoropyridine-2-carboxylate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M296360
- Product name
- Methyl6-bromo-5-fluoropyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- M13506
- Product name
- Methyl6-bromo-5-fluoropyridine-2-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC57015
- Product name
- Methyl6-bromo-5-fluoropyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 4H23-9-X2
- Product name
- Methyl 6-bromo-5-fluoropyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $183
- Updated
- 2021/12/16
Methyl 6-bromo-5-fluoropyridine-2-carboxylate Chemical Properties,Usage,Production
Synthesis
67-56-1
1052714-46-1
1210419-26-3
Synthesis of methyl 6-bromo-5-fluoro-pyridinecarboxylate: Concentrated sulfuric acid (4.2 eq.) was slowly added to a methanol (0.2 M) solution of 6-bromo-5-fluoro-2-pyridinecarboxylic acid (1.0 eq.) and the reaction mixture was stirred at room temperature. The progress of the reaction was monitored by LC/MS and the reaction was completed after about 2 hours. The reaction mixture was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution was added slowly to quench the reaction. The mixture was transferred to a partition funnel and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 6-bromo-5-fluoropyridinecarboxylate as a white solid (yield >99%). The product was characterized by LC/MS: m/z = 233.9/235.9 ([M+H]+), retention time Rt = 0.69 min.
References
[1] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 48
[2] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 65-66
[3] Patent: US2012/225062, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Patent: US2012/225061, 2012, A1. Location in patent: Page/Page column 22
[5] Patent: WO2013/175388, 2013, A1. Location in patent: Page/Page column 44
Methyl 6-bromo-5-fluoropyridine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 6-bromo-5-fluoropyridine-2-carboxylate manufacturers
- Product
- Methyl 6-bromo-5-fluoropyridine-2-carboxylate 1210419-26-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-12