5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester

Product Name: 5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester
CAS No.: 91229-86-6
Chemical Name: 5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester
Synonyms: N-Boc-5-bromo-L-norvaline tert-butyl ester;5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester;(S)-tert-Butyl 5-broMo-2-((tert-butoxycarbonyl)aMino)pentanoate;5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester USP/EP/BP;ert-butyl(2S)-5-bromo-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate;tert-butyl (2S)-5-bromo-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate;L-Norvaline, 5-bromo-N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester
CBNumber: CB82554347
Molecular Formula: C14H26BrNO4
Formula Weight: 352.26
MOL File: 91229-86-6.mol

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5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester Property

Boiling point:: 402.7±40.0 °C(Predicted)
Density: 1.218
storage temp.: 2-8°C
pka: 11.05±0.46(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS115489
Product name: (S)-tert-Butyl 5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate
Purity: 97+% ee
Packaging: 250mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 4967CS
Product name: (S)-Tert-Butyl5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate
Packaging: 1g
Price: $367
Updated: 2021/12/16

Activate Scientific

Product number: AS115489
Product name: (S)-tert-Butyl 5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate
Purity: 97+% ee
Packaging: 1g
Price: $545
Updated: 2021/12/16

Activate Scientific

Product number: AS115489
Product name: (S)-tert-Butyl 5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate
Purity: 97+% ee
Packaging: 5G
Price: $1383
Updated: 2021/12/16

Ambeed

Product number: A124533
Product name: (S)-tert-Butyl5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate
Purity: 95+%
Packaging: 100mg
Price: $79
Updated: 2021/12/16

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5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester Chemical Properties,Usage,Production

Synthesis

90194-99-3

91229-86-6

The general procedure for the synthesis of tert-butyl (S)-5-bromo-2-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate from (S)-2-((tert-butoxycarbonyl)amino)-5-hydroxypentanoic acid is as follows: 1. tert-Butyl (S)-2-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate (210.2 mg) was dissolved in dichloromethane (7.3 mL) and cooled to 0°C. 2. Carbon tetrabromide (1.5 eq.) and triphenylphosphine (2.0 eq.) were added sequentially and the reaction mixture was stirred at 0 °C for 20 min. 3. Upon completion of the reaction, the reaction was terminated with hexane/ethyl acetate (2:1, v/v). 4. The reaction mixture was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 2:1, v/v) to afford 254.6 mg (S)-tert-butyl 5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate in 100% yield as a colorless oil.

References

[1] Patent: EP2952504, 2015, A1. Location in patent: Paragraph 0151-0152
[2] European Journal of Organic Chemistry, 2004, # 21, p. 4391 - 4396
[3] Journal of Organic Chemistry, 1984, vol. 49, # 19, p. 3527 - 3534
[4] Chemistry Letters, 1996, # 8, p. 621 - 622

5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl ester Suppliers

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91229-86-6, 5-Bromo-N-[(tert-butoxy)carbonyl]-L-norvaline tert-butyl esterRelated Search:

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91229-86-6