2-Chloro-6-hydroxyquinoline
- Product Name
- 2-Chloro-6-hydroxyquinoline
- CAS No.
- 577967-89-6
- Chemical Name
- 2-Chloro-6-hydroxyquinoline
- Synonyms
- 2-chloroquinolin-6-ol;2-chloro-6-Quinolinol;6-Quinolinol, 2-chloro-;2-Chloro-6-hydroxyquinoline;577967-89-6
- CBNumber
- CB82554695
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 577967-89-6.mol
2-Chloro-6-hydroxyquinoline Property
- Melting point:
- 192℃
- Boiling point:
- 342.1±22.0 °C(Predicted)
- Density
- 1.412
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 8.62±0.40(Predicted)
- color
- Pale Beige
- InChI
- InChI=1S/C9H6ClNO/c10-9-4-1-6-5-7(12)2-3-8(6)11-9/h1-5,12H
- InChIKey
- XANCOYIVTNZKOE-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(O)=CC=2)C=CC=1Cl
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C429278
- Product name
- 2-Chloroquinolin-6-ol
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- C429278
- Product name
- 2-Chloroquinolin-6-ol
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- HCH0103949
- Product name
- 2-CHLORO-6-HYDROXY-QUINOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $197.4
- Updated
- 2021/12/16
- Product number
- OR954239
- Product name
- 2-Chloroquinolin-6-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- V6738
- Product name
- 2-Chloroquinolin-6-ol
- Packaging
- 5g
- Price
- $241
- Updated
- 2021/12/16
2-Chloro-6-hydroxyquinoline Chemical Properties,Usage,Production
Uses
2-Chloroquinolin-6-ol can be used for hair dye compositions.
Definition
ChEBI: 2-chloroquinolin-6-ol is a monohydroxyquinoline that is 6-hydroxyquinoline in which the hydrogen at position 2 is replaced by a chlorine. It is an organochlorine compound and a monohydroxyquinoline.
Synthesis
13676-02-3
577967-89-6
The general procedure for the synthesis of 2-chloro-6-hydroxyquinoline from 2-chloro-6-methoxyquinoline is as follows: General method: aryl methyl ether (1.0 eq.) was dissolved in dichloromethane (DCM, 10 mL) and cooled to 0 °C. Boron tribromide (BBr3, 5.0 eq.) was added slowly under stirring. The reaction mixture was stirred at 0 °C and then gradually warmed to room temperature and continued stirring at room temperature for 15 hours. Upon completion of the reaction, the reaction was quenched with sodium bicarbonate (NaHCO3) solution (50 mL) followed by extraction with DCM (4 x 10 mL). The organic layers were combined, washed with water (3 × 10 mL), dried over anhydrous sodium sulfate (Na2SO4), and finally concentrated under vacuum to obtain the target phenolic compounds. 2-Chloro-6-hydroxyquinoline (DHK-6-71) was prepared from 2 g scale of 2-chloro-6-methoxyquinoline using the above general method G. The product was a yellow solid in 93% (1.72 g) yield.
References
[1] Patent: CN102985411, 2016, B. Location in patent: Paragraph 0906-0908
[2] Patent: WO2012/48181, 2012, A1. Location in patent: Page/Page column 74
[3] Patent: WO2012/83165, 2012, A1. Location in patent: Page/Page column 91
[4] ACS Chemical Neuroscience, 2016, vol. 7, # 7, p. 897 - 911
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 4837
2-Chloro-6-hydroxyquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-hydroxyquinoline manufacturers
- Product
- 2-Chloro-6-hydroxyquinoline 577967-89-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-98%
- Supply Ability
- 200KG
- Release date
- 2019-09-03