4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester
- Product Name
- 4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester
- CAS No.
- 1203662-37-6
- Chemical Name
- 4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester
- Synonyms
- 4-Bromo-1H;3,2-DIOXABOROLAN-2-YL)THIOPHEN-2-YL);tert-Butyl 4-bromo-1H-indazol-5-carboxylate;4-Bromo-5-(tert-butoxycarbonyl)-1H-indazole;tert-Butyl 4-bromo-1H-indazole-5-carboxylate;1,1-Dimethylethyl 4-bromo-1H-indazole-5-carboxylate;4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester;4-Bromo-1H-indazole-5-carboxylic acid tert-butyl ester;1H-Indazole-5-carboxylic acid, 4-broMo-, 1,1-diMethylethyl ester
- CBNumber
- CB82554716
- Molecular Formula
- C12H13BrN2O2
- Formula Weight
- 297.15
- MOL File
- 1203662-37-6.mol
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester Property
- Boiling point:
- 404.0±25.0 °C(Predicted)
- Density
- 1.495±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.63±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B588683
- Product name
- tert-Butyl4-Bromo-1H-indazole-5-carboxylate
- Packaging
- 250mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- 3528AA
- Product name
- tert-Butyl4-bromo-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $374
- Updated
- 2021/12/16
- Product number
- HCH0369950
- Product name
- TERT-BUTYL-4-BROMO-1H-INDAZOLE-5-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.82
- Updated
- 2021/12/16
- Product number
- OR305101
- Product name
- tert-Butyl 4-bromo-1H-indazole-5-carboxylate
- Packaging
- 100mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- OR305101
- Product name
- tert-Butyl 4-bromo-1H-indazole-5-carboxylate
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Uses
tert-Butyl 4-Bromo-1H-indazole-5-carboxylate could be prepared as inhibitors of MNK1 and MNK2, which are useful in treating MNK-mediated diseases.
Synthesis
1203662-35-4
1203662-37-6
Step 3: Synthesis of tert-butyl 4-bromo-1H-indazole-5-carboxylate [0245] Tert-butyl 2-bromo-4-fluoro-3-formylbenzoate (4.25 g, 14 mmol) was dissolved in DME (25 mL), hydrazine hydrate (15 mL) was added, and the reaction was heated for 1 hr at 90 °C. After completion of the reaction, it was cooled to room temperature and the reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give tert-butyl 4-bromo-1H-indazole-5-carboxylate as a brown solid (4.1 g, 100% yield). LCMS (Method B): retention time (Rx) = 3.63 min, [M + CH3CN + H]+ = 338/340, [M-H]? = 295/297.
References
[1] Patent: WO2010/3025, 2010, A1. Location in patent: Page/Page column 63
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 10, p. 4594 - 4604
4-BroMo-1H-indazol-5-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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