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PLATELET ACTIVATING FACTOR-16, ANTAGONIST

Product Name
PLATELET ACTIVATING FACTOR-16, ANTAGONIST
CAS No.
137566-83-7
Chemical Name
PLATELET ACTIVATING FACTOR-16, ANTAGONIST
Synonyms
HEXANOLAMINO PAF C-16;IJAODKNFSHBTDQ-SSEXGKCCSA-N;PLATELET ACTIVATING FACTOR-16, ANTAGONIST;1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphono(N,N,N-trimethyl)hexanolamine;1-O-HEXADECYL-2-ACETYL-SN-GLYCEROL-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)-HEXANOLAMINE;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE;L-ALPHA-PHOSPHATIDYL(N,N,N-TRIMETHYL)HEXANOLAMINE, BETA-ACETYL, GAMMA-HEXADECYL;1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYL(N,N,N-TRIMETHYL) HEXANOLAMINE;7,9,13-Trioxa-8-phosphanonacosan-1-aminium, 11-(acetyloxy)-8-hydroxy-N,N,N-trimethyl-, inner salt, 8-oxide, (11R)-
CBNumber
CB8256061
Molecular Formula
C30H62NO7P
Formula Weight
579.79
MOL File
137566-83-7.mol
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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Property

storage temp. 
−20°C
solubility 
≤23mg/ml in ethanol;0.5mg/ml in DMSO;1.5mg/ml in dimethyl formamide
form 
lyophilized powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
60905
Product name
Hexanolamino PAF C-16
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
60905
Product name
Hexanolamino PAF C-16
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
60905
Product name
Hexanolamino PAF C-16
Purity
≥98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
60905
Product name
Hexanolamino PAF C-16
Purity
≥98%
Packaging
25mg
Price
$448
Updated
2024/03/01
ApexBio Technology
Product number
C5373
Product name
HexanolaminoPAFC-16
Packaging
25mg
Price
$510
Updated
2021/12/16
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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Chemical Properties,Usage,Production

Uses

1-O-Hexadecyl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)-hexanolamine is a PAF antagonist.

Definition

ChEBI: 1-o-hexadecyl-2-o-acetyl-sn-glyceryl-3-phosphoryl(n,n,n-trimethyl)hexanolamine is a glycerophospholipid.

Biological Activity

hexanolamino paf c-16 is a paf analog with paf agonist/antagonist properties.platelet activating factor (paf; c16), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages [1].hexanolamino paf c-16, a paf analog with an increased inter-ionic distance in the polar head group, showed a greater potency in macrophages than platelets. in human monocyte-derived macrophages, hexanolamino paf c-16 was an antagonist and specifically inhibited the generation of superoxide ion (02-) and hydrogen peroxide (h202) in response to paf [1]. in both rabbit platelets and guinea-pig macrophages, hexanolamino paf c-16 acted as a partial agonist [2].

References

[1]. rouis m, nigon f, chapman mj. platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. biochem biophys res commun. 1988 nov 15;156(3):1293-301.
[2]. stewart ag, grigoriadis g. structure-activity relationships for platelet-activating factor (paf) and analogues reveal differences between paf receptors on platelets and macrophages. j lipid mediat. 1991 nov;4(3):299-308.

PLATELET ACTIVATING FACTOR-16, ANTAGONIST Preparation Products And Raw materials

Raw materials

Preparation Products

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PLATELET ACTIVATING FACTOR-16, ANTAGONIST Suppliers

Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
68144
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58

137566-83-7, PLATELET ACTIVATING FACTOR-16, ANTAGONISTRelated Search:


  • PLATELET ACTIVATING FACTOR-16, ANTAGONIST
  • 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)-HEXANOLAMINE
  • 1-O-HEXADECYL-2-ACETYL-SN-GLYCEROL-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE
  • 1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERYL-3-PHOSPHORYL(N,N,N-TRIMETHYL) HEXANOLAMINE
  • 1-O-HEXADECYL-2-O-ACETYL-SN-GLYCERO-3-PHOSPHO-(N,N,N-TRIMETHYL)HEXANOLAMINE
  • L-ALPHA-PHOSPHATIDYL(N,N,N-TRIMETHYL)HEXANOLAMINE, BETA-ACETYL, GAMMA-HEXADECYL
  • HEXANOLAMINO PAF C-16
  • 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphono(N,N,N-trimethyl)hexanolamine
  • IJAODKNFSHBTDQ-SSEXGKCCSA-N
  • 7,9,13-Trioxa-8-phosphanonacosan-1-aminium, 11-(acetyloxy)-8-hydroxy-N,N,N-trimethyl-, inner salt, 8-oxide, (11R)-
  • 137566-83-7
  • C30H62NO7P