6-cyclopropylpyridin-3-aMine

Product Name: 6-cyclopropylpyridin-3-aMine
CAS No.: 1159821-66-5
Chemical Name: 6-cyclopropylpyridin-3-aMine
Synonyms: 6-Cyclopropyl-3-pyridinamine;6-cyclopropylpyridin-3-aMine;5-Amino-2-cyclopropylpyridine;6-cyclopropylpyridine-3-amine;3-Pyridinamine, 6-cyclopropyl-
CBNumber: CB82563035
Molecular Formula: C8H10N2
Formula Weight: 134.18
MOL File: 1159821-66-5.mol

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6-cyclopropylpyridin-3-aMine Property

Boiling point:: 310.0±30.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.84±0.22(Predicted)
Appearance: Light yellow to brown Solid-Liquid Mixture

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 3H30-1-BF
Product name: 6-Cyclopropylpyridin-3-amine
Packaging: 250mg
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: 0850DG
Product name: 6-Cyclopropylpyridin-3-amine
Packaging: 100mg
Price: $107
Updated: 2021/12/16

Apolloscientific

Product number: OR306607
Product name: 6-Cyclopropylpyridin-3-amine
Packaging: 1g
Price: $216
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-BF
Product name: 6-Cyclopropylpyridin-3-amine
Packaging: 1g
Price: $256
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0391296
Product name: 6-CYCLOPROPYLPYRIDIN-3-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $499.5
Updated: 2021/12/16

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6-cyclopropylpyridin-3-aMine Chemical Properties,Usage,Production

Synthesis

1190380-55-2

1159821-66-5

2-Cyclopropyl-5-nitropyridine (300 mg, 2.24 mmol) was used as starting material and mixed with 10% palladium/carbon catalyst (32 mg) in ethanol (15 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated to obtain the crude product. To improve the conversion, the crude product was reacted again under the same hydrogenation conditions and separated as described previously. Finally, the crude product was purified by preparative HPLC (high pH buffer) to afford the target compound 6-cyclopropylpyridin-3-amine as an orange oil (30 mg, 12% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 0.85-1.06 (m, 4H), 1.98-2.09 (m, 1H), 3.78-4.07 (m, 2H), 6.93 (d, J = 7.79 Hz, 1H), 7.01 (dd, J = 8.24, 2.75 Hz, 1H), 8.06 (d, J = 3.21 Hz, 1H); mass spectrum (ES+APCI+): m/z 135 [M+H]+.

References

[1] Patent: WO2009/122180, 2009, A1. Location in patent: Page/Page column 115

6-cyclopropylpyridin-3-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-cyclopropylpyridin-3-aMine Suppliers

China 38 India 1 United Kingdom 1 United States 3 Global 43

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1159821-66-5, 6-cyclopropylpyridin-3-aMineRelated Search:

6-cyclopropylpyridin-3-aMine

6-Cyclopropyl-3-pyridinamine

5-Amino-2-cyclopropylpyridine

3-Pyridinamine, 6-cyclopropyl-

6-cyclopropylpyridine-3-amine

1159821-66-5