1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole
- Product Name
- 1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole
- CAS No.
- 294877-29-5
- Chemical Name
- 1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole
- Synonyms
- 1-(3-Bromophenyl)-3,5-dimethylpyrazole;1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole;1H-Pyrazole, 1-(3-bromophenyl)-3,5-dimethyl-
- CBNumber
- CB82563565
- Molecular Formula
- C11H11BrN2
- Formula Weight
- 251.12
- MOL File
- 294877-29-5.mol
1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole Property
- Boiling point:
- 327.6±30.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.38±0.12(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B698210
- Product name
- 1-(3-Bromophenyl)-3,5-dimethylpyrazole
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- V4976
- Product name
- 1-(3-Bromophenyl)-3,5-dimethylpyrazole
- Packaging
- 5g
- Price
- $161
- Updated
- 2021/12/16
- Product number
- 129267
- Product name
- 1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazole
- Purity
- 95%+
- Packaging
- 1g
- Price
- $342
- Updated
- 2021/12/16
- Product number
- HCH0361867
- Product name
- 1-(3-BROMOPHENYL)-3,5-DIMETHYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.48
- Updated
- 2021/12/16
- Product number
- 129267
- Product name
- 1-(3-Bromo-phenyl)-3,5-dimethyl-1H-pyrazole
- Purity
- 95%+
- Packaging
- 5g
- Price
- $1170
- Updated
- 2021/12/16
1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole Chemical Properties,Usage,Production
Synthesis
27246-81-7
123-54-6
294877-29-5
A solution was prepared from 3-bromophenylhydrazine hydrochloride (45 g, 200 mmol) and acetylacetone (30.2 g, 302 mmol) in dichloromethane (225 mL). Concentrated sulfuric acid (1.073 mL, 20.13 mmol) was slowly added to the solution under nitrogen protection and the reaction was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was diluted with dichloromethane (500 mL) and washed with deionized water (2 x 250 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography on silica gel (100-200 mesh) with hexane solution of 5% ethyl acetate as eluent to afford 1-(3-bromophenyl)-3,5-dimethyl-1H-pyrazole (59% yield) as a light brown liquid.1H NMR (CDCl3, 400 MHz) δ: 7.71 (t, J = 2 Hz, 1H), 7.57-7.49 (m 2H), 7.46-7.40 (t, J = 8 Hz, 1H), 6.07 (s, 1H), 2.31 (s, 3H), 2.18 (s, 3H).
References
[1] Organic and Biomolecular Chemistry, 2016, vol. 14, # 25, p. 5992 - 6009
[2] Patent: WO2014/154725, 2014, A1. Location in patent: Page/Page column 33
1-(3-Bromophenyl)-3,5-dimethyl-1H-pyrazole Preparation Products And Raw materials
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