1,4-DIBROMO-2,3-DIMETHYLBENZENE
- Product Name
- 1,4-DIBROMO-2,3-DIMETHYLBENZENE
- CAS No.
- 75024-22-5
- Chemical Name
- 1,4-DIBROMO-2,3-DIMETHYLBENZENE
- Synonyms
- 1 4-DIBROMO;1,4-DIBROMO-O-XYLENE;3,6-Dibromo-o-xylene;Ibandronate Impurity 33;Dexmedetomidine Impurity 41;1,4-DIBROMO-2,3-DIMETHYLBENZENE;1,4-DIBROMO-2,3-DIMETHYLBENZENEA;2, 3-dimethyl-1, 4-dibromobenzene;Benzene,1,4-dibromo-2,3-dimethyl-
- CBNumber
- CB8256526
- Molecular Formula
- C8H8Br2
- Formula Weight
- 263.96
- MOL File
- 75024-22-5.mol
1,4-DIBROMO-2,3-DIMETHYLBENZENE Property
- Melting point:
- 232 °C
- Boiling point:
- 118-121 °C(Press: 15 Torr)
- Density
- 1.710±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H8Br2/c1-5-6(2)8(10)4-3-7(5)9/h3-4H,1-2H3
- InChIKey
- IVJJDBCZDJFMNZ-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(Br)C(C)=C1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD75270
- Product name
- 1,4-dibromo-2,3-dimethylbenzene
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 037664
- Product name
- 3,6-Dibromo-o-xylene
- Purity
- 95%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FD75270
- Product name
- 1,4-dibromo-2,3-dimethylbenzene
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FD75270
- Product name
- 1,4-dibromo-2,3-dimethylbenzene
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FD75270
- Product name
- 1,4-dibromo-2,3-dimethylbenzene
- Packaging
- 2g
- Price
- $200
- Updated
- 2021/12/16
1,4-DIBROMO-2,3-DIMETHYLBENZENE Chemical Properties,Usage,Production
Chemical Properties
White to Yellow Solid
Uses
1,4-Dibromo-2,3-dimethylbenzene is an organic compound containing two bromine atoms and two methyl groups on its benzene ring structure, which can be used to prepare pharmaceutical and chemical intermediates.
Synthesis
1338796-79-4
75024-22-5
The general procedure for the synthesis of 1,4-dibromo-2,3-dimethylbenzene from 4-bromo-2,3-dimethylaniline hydrobromide was as follows: first, a solution of free base 3b was prepared. 4-Bromo-2,3-dimethylaniline hydrobromide (8.69 g, 43.5 mmol) was suspended in Et2O (20 mL), Na2CO3 (5 g, 50 mmol) and H2O (5 mL) were added, stirred, and then filtered and the solvent was evaporated to obtain the free base 3b.Next, the free base 3b was dissolved in MeCN (100 mL), and this solution was added to the MeCN (200 mL) solution containing CuBr2 (9.71 g, 43.5 mmol, 1 eq.) and tBuONO (4.93 g, 5.68 mL, 47.8 mmol, 1.1 eq.). The reaction mixture was stirred at room temperature for 16 hours and then at 82 °C for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with AcOEt (200 mL), washed sequentially with brine (2 x 100 mL), dried (MgSO4), and the solvent was evaporated to afford the target product 1,4-dibromo-2,3-dimethylbenzene (9.79 g, 85% yield). The NMR data of the product were in agreement with those reported in the literature ref15.
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 18, p. 5716 - 5733
1,4-DIBROMO-2,3-DIMETHYLBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,4-DIBROMO-2,3-DIMETHYLBENZENE manufacturers
- Product
- 1,4-DIBROMO-2,3-DIMETHYLBENZENE 75024-22-5
- Price
- US $80.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-27
- Product
- 1,4-DIBROMO-2,3-DIMETHYLBENZENE 75024-22-5
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-12