ChemicalBook > CAS DataBase List > CID 5951923

CID 5951923

Product Name
CID 5951923
CAS No.
749872-43-3
Chemical Name
CID 5951923
Synonyms
AC1NZ6UQ;CID 5951923;KLF5 Inhibitor, CID 5951923;KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem;[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
CBNumber
CB82574686
Molecular Formula
C16H18N2O7S
Formula Weight
382.39
MOL File
749872-43-3.mol
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CID 5951923 Property

Boiling point:
646.9±55.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: soluble10mg/mL (clear solution)
form 
powder
pka
-1.40±0.20(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
422625
Product name
KLF5 Inhibitor, CID 5951923
Packaging
10mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0375
Product name
CID 5951923
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2022/05/15
Cayman Chemical
Product number
21649
Product name
CID 5951923
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21649
Product name
CID 5951923
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
21649
Product name
CID 5951923
Purity
≥98%
Packaging
10mg
Price
$139
Updated
2024/03/01
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CID 5951923 Chemical Properties,Usage,Production

Uses

This compound acts as a KLF-5 expression inhibitor. which in turn reduces proliferation cell rates in colorectal cancer cells in humans.

General Description

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 μM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.

CID 5951923 Preparation Products And Raw materials

Raw materials

Preparation Products

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CID 5951923 Suppliers

Canada 1 China 43 United Kingdom 2 United States 11 Global 57
J & K SCIENTIFIC LTD.
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749872-43-3, CID 5951923Related Search:


  • CID 5951923
  • 3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester
  • 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester
  • [2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate
  • AC1NZ6UQ
  • 3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me
  • KLF5 Inhibitor, CID 5951923
  • KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem
  • 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl (E)-3-(3-nitrophenyl)prop-2-enoate
  • 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl 3-(3-nitrophenyl)acrylate
  • Krüppel-like factor,CID-5951923,CID5951923,KLF5,inhibit,cancer,factor,KLF,transcription,Inhibitor,Krüppel-like,CID 5951923
  • 2-Propenoic acid, 3-(3-nitrophenyl)-, 2-[methyl(tetrahydro-1,1-dioxido-3-thienyl)amino]-2-oxoethyl ester
  • 749872-43-3
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals