5-Fluoro-2-Methyl-3-nitrobenzoic acid
Uses- Product Name
- 5-Fluoro-2-Methyl-3-nitrobenzoic acid
- CAS No.
- 850462-64-5
- Chemical Name
- 5-Fluoro-2-Methyl-3-nitrobenzoic acid
- Synonyms
- 5-Fluoro-3-nitro-o-toluic acid;Benzoic acid, 5-fluoro-2-Methyl-3-nitro-;5-Fluoro-2-Methyl-3-nitrobenzoic acid ISO 9001：2015 REACH
- CBNumber
- CB82583066
- Molecular Formula
- C8H6FNO4
- Formula Weight
- 199.14
- MOL File
- 850462-64-5.mol
5-Fluoro-2-Methyl-3-nitrobenzoic acid Property
- Boiling point:
- 337.9±42.0 °C(Predicted)
- Density
- 1.482±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.69±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B441518
- Product name
- 5-fluoro-2-methyl-3-nitrobenzoicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-M2036
- Product name
- Benzoicacid,5-fluoro-2-methyl-3-nitro-
- Purity
- 98.81%
- Packaging
- 5g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- CS-M2036
- Product name
- Benzoicacid,5-fluoro-2-methyl-3-nitro-
- Purity
- 98.81%
- Packaging
- 10g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- CS-M2036
- Product name
- Benzoicacid,5-fluoro-2-methyl-3-nitro-
- Purity
- 98.81%
- Packaging
- 25g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- Y5110
- Product name
- 5-Fluoro-2-methyl-3-nitrobenzoicacid
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
5-Fluoro-2-Methyl-3-nitrobenzoic acid Chemical Properties,Usage,Production
Uses
5-Fluoro-2-methyl-3-nitrobenzoic acid can be used in organic synthesis, pharmaceutical intermediates, etc.
Synthesis
33184-16-6
850462-64-5
General procedure for the synthesis of 5-fluoro-2-methyl-3-nitrobenzoic acid (D135) from 2-methyl-5-fluorobenzoic acid: 2-methyl-5-fluorobenzoic acid (20 g) was added in batches to ice-cooled concentrated sulfuric acid (98%, 80 mL), and stirred until all solids were dissolved. A mixture of nitric acid (65%, 6 mL) and concentrated sulfuric acid (98%, 12 mL) was slowly added dropwise at 0°C. The solution was then mixed with a mixture of nitric acid (65%, 6 mL) and concentrated sulfuric acid (98%, 12 mL). After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature and stirring was continued for 6 hours. Upon completion of the reaction, the mixture was slowly poured into ice (500 g) to quench the reaction and precipitate a solid. The solid was collected by filtration and washed with water (100 mL). The solid was redissolved in ethyl acetate (200 mL) and the organic layer was washed with saturated brine. The organic layer was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give the title compound (11 g) as a brown solid.1H NMR (400 MHz, MeOD-d4): δ 7.84 (dd, J = 8.7, 2.6 Hz, 1H), 7.78 (dd, J = 7.8, 2.8 Hz, 1H), 2.55 (s, 3H).MS (ESI ): m/z calculated value C8H6FNO4 [M-H]- 198, measured value 198.
References
[1] Patent: US2005/131226, 2005, A1. Location in patent: Page/Page column 6-7
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 9, p. 2063 - 2072
[3] Patent: WO2005/35518, 2005, A1. Location in patent: Page/Page column 19
[4] Patent: EP2098513, 2009, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2005/28445, 2005, A2. Location in patent: Page/Page column 29-30
5-Fluoro-2-Methyl-3-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-Methyl-3-nitrobenzoic acid manufacturers
- Product
- 5-Fluoro-2-Methyl-3-nitrobenzoic acid 850462-64-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg; 2kg；10kg; 100kg
- Release date
- 2019-08-30