ChemicalBook > CAS DataBase List > 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester

3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester

Product Name: 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
CAS No.: 634911-80-1
Chemical Name: 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
Synonyms: abs818554;BOC-D-FMK, 10 mM in DMSO;Caspase Inhibitor Boc-D-FMK;Caspase3-Inhibitor Boc-D-FMK;1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-;BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK;BOC-d-FMK /PAN-CASPASE INHIBITOR BOC-D-FMK / 634911-80-1;Methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate;3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester;Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
CBNumber: CB82589624
Molecular Formula: C11H18FNO5
Formula Weight: 263.26
MOL File: 634911-80-1.mol

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3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Property

Boiling point:: 383.5±37.0 °C(Predicted)
Density: 1.150
storage temp.: -20°C
solubility: DMSO: 5mg/mL
form: <31.2°C Solid,>31.2°C Liquid
pka: 10.12±0.46(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)
InChIKey: MXOOUCRHWJYCAL-UHFFFAOYSA-N
SMILES: C(OC)(=O)CC(NC(OC(C)(C)C)=O)C(=O)CF

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 218745
Product name: Caspase Inhibitor III - CAS 634911-80-1 - Calbiochem
Purity: The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 250μG
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: 218745
Product name: Caspase Inhibitor III - CAS 634911-80-1 - Calbiochem
Purity: The Caspase Inhibitor III, also referenced under CAS 634911-80-1, controls the biological activity of Caspase. This small molecule/inhibitor is primarily used for Cancer applications.
Packaging: 1MG
Price: $272
Updated: 2024/03/01

Crysdot

Product number: CD31001218
Product name: BOC-D-FMK
Purity: 98+%
Packaging: 5mg
Price: $98
Updated: 2021/12/16

Crysdot

Product number: CD31001218
Product name: BOC-D-FMK
Purity: 98+%
Packaging: 10mg
Price: $146
Updated: 2021/12/16

DC Chemicals

Product number: DC23218
Product name: BOC-D-FMK
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

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3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Chemical Properties,Usage,Production

Uses

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM.

Biological Activity

Cell permeable: yes', 'Primary Target
broad spectrum caspase', 'Product does not compete with ATP.', 'Reversible: no

in vivo

Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge^[3]. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle^[4].

IC 50

Caspase

References

[1] Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. DOI:10.1182/blood-2004-07-2870
[2] Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42. DOI:10.1038/emm.2006.75
[3] Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9. DOI:10.1111/j.1440-1746.2008.05368.x
[4] Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181(2):190-203. DOI:10.1016/s0014-4886(03)00023-2

3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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634911-80-1, 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl esterRelated Search:

3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester

Caspase3-Inhibitor Boc-D-FMK

Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester

BOC-D-FMK (Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester)

1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-

Caspase Inhibitor Boc-D-FMK

abs818554

BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK

Methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate

BOC-D-FMK, 10 mM in DMSO

BOC-d-FMK /PAN-CASPASE INHIBITOR BOC-D-FMK / 634911-80-1

634911-80-1

C11H18FNO5