CUDA
- Product Name
- CUDA
- CAS No.
- 479413-68-8
- Chemical Name
- CUDA
- Synonyms
- CUDA;CUDA Exclusive;CUDA, 10 mM in DMSO;HPTJABJPZMULFH-UHFFFAOYSA-N;Dodecanoic acid, 12-[[(cyclohexylamino)carbonyl]amino]-;PPARalpha,epoxide,Peroxisome proliferator-activated receptors,cardiovascular,Inhibitor,peroxisome,Soluble,inhibit,disease,receptor,sEH,proliferator-activated,PPAR,Epoxide Hydrolase,hypotensive,CUDA,PPARα,hydrolase,lipid-lowering
- CBNumber
- CB82590750
- Molecular Formula
- C19H36N2O3
- Formula Weight
- 340.5
- MOL File
- 479413-68-8.mol
CUDA Property
- Boiling point:
- 549.4±19.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤1mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 4.78±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10007923
- Product name
- CUDA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 10007923
- Product name
- CUDA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 10007923
- Product name
- CUDA
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- 10007923
- Product name
- CUDA
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- C3620
- Product name
- CUDA
- Packaging
- 10mg
- Price
- $74
- Updated
- 2021/12/16
CUDA Chemical Properties,Usage,Production
Uses
CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].
Definition
ChEBI: 12-[(Cyclohexylcarbamoyl)amino]dodecanoic acid is a medium-chain fatty acid.
Biological Activity
cuda is a soluble epoxide hydrolase (seh) inhibitor.epoxyeicosatrienoic acid metabolites of arachidonic acid, such as 11(12)-eet and 14(15)-eet, have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. soluble epoxide hydrolase (seh) can catalyze the conversion of eets to the corresponding dihydroxy eicosatrienoic acids thereby diminishing their activity.
in vitro
in a previous study, in order to test if the cuda’s mechanism of action is retained upon structural modification, the dissociation constants of cuda was evaluated for mouse seh. results showed that for cuda, competitive a tight-binding inhibition kinetic was obtained with r2 > 0.99. moreover, the ki value of 3.8 nm was obtained for cuda. in addition, it was found that cuda was an inhibitor of seh exhibiting ic50 values of 11.1 nm and 112 nm for the mouse and human enzymes, respectively [1].
IC 50
11.1 and 112 nm for the mouse and human soluble epoxide hydrolase, respectively
References
[1] c. morisseau, m. h. goodrow, j. w. newman, et al. structural refinement of inhibitors of urea-based soluble epoxide hydrolases. biochemical pharmacology 63, 1599-1608 (2002).
CUDA Preparation Products And Raw materials
Raw materials
Preparation Products
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