GW 848687X

Product Name: GW 848687X
CAS No.: 612831-24-0
Chemical Name: GW 848687X
Synonyms: GW 848687X;PFODPHDNBFSMOX-UHFFFAOYSA-N;2-Pyridinecarboxylic acid, 6-[2-[5-chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-
CBNumber: CB82591191
Molecular Formula: C24H18ClF2NO3
Formula Weight: 441.85
MOL File: 612831-24-0.mol

More

Less

GW 848687X Property

Boiling point:: 622.8±55.0 °C(Predicted)
Density: 1.393±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
pka: 1.09±0.50(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010410
Product name: GW 848687X
Purity: ≥98%
Packaging: 500μg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 10010410
Product name: GW 848687X
Purity: ≥98%
Packaging: 1mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 10010410
Product name: GW 848687X
Purity: ≥98%
Packaging: 5mg
Price: $700
Updated: 2024/03/01

AK Scientific

Product number: 6220CR
Product name: 6-[2-[5-Chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopentenyl]pyridine-2-carboxylicAcid
Packaging: 5mg
Price: $877
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0028425
Product name: 6-(2-(5-CHLORO-2-((2,4-DIFLUOROPHENYL)METHOXY)PHENYL)-1-CYCLOPENTEN-1-YL)-2-PYRIDINECARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $994.9
Updated: 2021/12/16

More

Less

GW 848687X Chemical Properties,Usage,Production

Uses

GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain[1].

in vivo

GW 848687X (30 mg/kg; po; b.i.d, 5 d) exhibits antihyperalgesic activity in an FCA-induced inflammatory joint pain model^[1].

Animal Model:	FCA induced joint pain model of inflammatory pain^[1]
Dosage:	30mg/kg
Administration:	po; twice daily for 5 days
Result:	Completely reversed pain sensation in rats and had anti-pain effects.

References

[1] Giblin GM, et al. The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. DOI:10.1016/j.bmcl.2006.10.041

GW 848687X Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GW 848687X Suppliers

China 27 United States 3 Global 30

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24964
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

612831-24-0, GW 848687XRelated Search:

GW 848687X

PFODPHDNBFSMOX-UHFFFAOYSA-N

2-Pyridinecarboxylic acid, 6-[2-[5-chloro-2-[(2,4-difluorophenyl)methoxy]phenyl]-1-cyclopenten-1-yl]-

612831-24-0