ChemicalBook > CAS DataBase List > PSN632408

PSN632408

Product Name
PSN632408
CAS No.
857652-30-3
Chemical Name
PSN632408
Synonyms
PSN632408;PSN632408,PSN-632408;PSN 632408; PSN-632408; PSN 632408; PSN-632408;tert-butyl 4-((3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methoxy)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester
CBNumber
CB82592279
Molecular Formula
C18H24N4O4
Formula Weight
360.41
MOL File
857652-30-3.mol
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PSN632408 Property

Boiling point:
513.8±60.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
0.79±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10008594
Product name
PSN632408
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10008594
Product name
PSN632408
Purity
≥98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
10008594
Product name
PSN632408
Purity
≥98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
10008594
Product name
PSN632408
Purity
≥98%
Packaging
25mg
Price
$448
Updated
2024/03/01
ApexBio Technology
Product number
B4694
Product name
PSN632408
Packaging
10mg
Price
$227
Updated
2021/12/16
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PSN632408 Chemical Properties,Usage,Production

Uses

PSN632408, a selective, orally active GPR119 agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders[1][2].

Biological Activity

psn632408 is a novel, selective and small-molecule agonist of human and mouse gpr119 with ec50 values of 5.6±0.99 μm and 7.9±0.7 μm, respectively [1].psn632408 has been reported to activate human and mouse gpr119 in a yeast fluorimetric assay with ec50 of 5.6±0.99 μm and 7.9±0.7 μm, respectively. in hek-osgpr116 cells, camp level was dose-dependently increased by psn632408 with an ec50 of 1.9±0.14 μm.. in vivo, psn632408 induced food intake reduction by using a rat feeding model and acute hypophagic effects in dose-dependence [1].

in vivo

PSN632408 (100 mg/kg; p.o.; daily for 14 days) suppresses food intake in rats and reduce body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats[1].

Animal Model:Diet-induced obese (DIO) rats[1]
Dosage:100 mg/kg
Administration:P.o.; daily for 14 days
Result:The mean daily food intake was decreased by 10% during the first week of dosing and 15% during the second week. Body weight gain was significantly attenuated from day 6 onward with some evidence of weight loss.

References

[1] overton ha1, babbs aj, doel sm, fyfe mc, gardner ls, griffin g, jackson hc, procter mj, rasamison cm, tang-christensen m, widdowson ps, williams gm, reynet c.deorphanization of a g protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. cell metab. 2006 mar;3(3):167-75

PSN632408 Preparation Products And Raw materials

Raw materials

Preparation Products

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PSN632408 Suppliers

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857652-30-3, PSN632408Related Search:


  • PSN632408
  • PSN 632408; PSN-632408; PSN 632408; PSN-632408
  • tert-butyl 4-((3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)methoxy)piperidine-1-carboxylate
  • 1-Piperidinecarboxylic acid, 4-[[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methoxy]-, 1,1-dimethylethyl ester
  • PSN632408,PSN-632408
  • 857652-30-3