ChemicalBook > CAS DataBase List > 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-

Product Name
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
CAS No.
918504-27-5
Chemical Name
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
Synonyms
B-Raf IN 11;ZINC72115182;ZINC-72115182,ZINC72115182;B-Raf IN 11, 10 mM in DMSO;N-[3-(5-Bromo-7-azaindole-3-carbonyl)-2,4-difluorophenyl]-1-propanesulfonamide;N-(3-(5-broMo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;N-{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-;Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]amide,
CBNumber
CB82595245
Molecular Formula
C17H14BrF2N3O3S
Formula Weight
458.28
MOL File
918504-27-5.mol
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1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Property

Density 
1.689±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.19±0.10(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0369680
Product name
N-(3-(5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULFONAMIDE
Purity
95.00%
Packaging
5MG
Price
$495.67
Updated
2021/12/16
Matrix Scientific
Product number
100551
Product name
N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
AK Scientific
Product number
5505AC
Product name
N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Packaging
250mg
Price
$1051
Updated
2021/12/16
Matrix Scientific
Product number
100551
Product name
N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
Chemenu
Product number
CM149556
Product name
N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
Purity
95%+
Packaging
5g
Price
$1397
Updated
2021/12/16
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1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Chemical Properties,Usage,Production

Uses

B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]

Synthesis

1103234-56-5

183208-35-7

918504-27-5

General method: 2,6-Difluoro-3-(propylsulfonamido)benzoic acid (1.1 eq.) was suspended in anhydrous dichloromethane (DCM, 0.5 M), oxalyl chloride (1.05 eq.) and a catalytic amount of N,N-dimethylformamide (DMF, a few drops) were added sequentially. The reaction mixture was stirred at room temperature until gas release ceased. Subsequently, the resulting chloride solution was slowly added dropwise to a suspension of anhydrous DCM (0.5 M) containing 5-bromo-7-azaindole (1 eq.) and anhydrous aluminum trichloride (AlCl3, 5 eq.). The reaction mixture was continued to be stirred at room temperature for 0.5 to 3 hours. Upon completion of the reaction, saturated aqueous ammonium chloride (NH4Cl) was added to quench the reaction. The aqueous phase was extracted with ethyl acetate (EtOAc, 3 times) and the combined organic layers were dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography using silica gel (SiO2) as stationary phase and n-hexane/ethyl acetate (1:1, v/v) or dichloromethane/methanol (the methanol content was increased in a gradient from 0.5% to 5%, and ultimately did not exceed 3%, v/v) to afford the target compound N-[3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl) carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide.

IC 50

B-RafV600E: 76 nM (IC50); BRAFWT: 238 nM (IC50)

References

[1] Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim). 2016 Oct;349(10):808-815. DOI:10.1002/ardp.201600184

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Suppliers

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Jinan Trio PharmaTech Co., Ltd.
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View Lastest Price from 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- manufacturers

Career Henan Chemical Co
Product
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- 918504-27-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-15

918504-27-5, 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-Related Search:


  • 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
  • N-(3-(5-broMo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
  • N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
  • Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]amide,
  • ZINC72115182
  • B-Raf IN 11
  • ZINC-72115182,ZINC72115182
  • N-[3-(5-Bromo-7-azaindole-3-carbonyl)-2,4-difluorophenyl]-1-propanesulfonamide
  • N-{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
  • B-Raf IN 11, 10 mM in DMSO
  • 918504-27-5
  • C17H14BrF2N3O3S