4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine

Product Name: 4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine
CAS No.: 438554-45-1
Chemical Name: 4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine
Synonyms: 4-Chloro-5-nitro-2-(trifluoromethyl);4-Chloro-2-(trifluoroMethyl)-5-nitropyridine;4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine;Pyridine, 4-chloro-5-nitro-2-(trifluoromethyl)-;4-Chloro-5-nitro-alpha,alpha,alpha-trifluoro-2-picoline
CBNumber: CB82595573
Molecular Formula: C6H2ClF3N2O2
Formula Weight: 226.54
MOL File: 438554-45-1.mol

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4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine Property

Boiling point:: 231.6±40.0 °C(Predicted)
Density: 1.618±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.91±0.10(Predicted)
form: liquid
color: Yellow
InChI: InChI=1S/C6H2ClF3N2O2/c7-3-1-5(6(8,9)10)11-2-4(3)12(13)14/h1-2H
InChIKey: VBVLYVRVIUJULO-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=C([N+]([O-])=O)C(Cl)=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C385948
Product name: 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: PC51213
Product name: 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine
Packaging: 250mg
Price: $228
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-7-X5
Product name: 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine
Packaging: 250mg
Price: $252
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044312
Product name: 4-CHLORO-2-(TRIFLUOROMETHYL)-5-NITROPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $498.88
Updated: 2021/12/16

Matrix Scientific

Product number: 126706
Product name: 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine
Purity: >95%
Packaging: 1g
Price: $1044
Updated: 2021/12/16

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4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine Chemical Properties,Usage,Production

Synthesis

438554-44-0

438554-45-1

General procedure for the synthesis of 4-chloro-5-nitro-2-trifluoromethylpyridine from 5-nitro-2-(trifluoromethyl)pyridin-4-ol: to a stirred mixed solution of 5-nitro-2-(trifluoromethyl)pyridin-4-ol (3.9 g, 0.01 mol), PCl5 (4.5 g, 0.02 mol) and POCl3 (2 mL, 0.02 mol) The reaction was heated to 80°C for 16 hours. The reaction progress was monitored by TLC to confirm the completion of the reaction. The reaction mixture was cooled to room temperature, diluted with dichloromethane (DCM) and washed sequentially with water (100 mL), saturated NaHCO3 solution (100 mL) and brine (100 mL). The organic phase was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-chloro-5-nitro-2-(trifluoromethyl)pyridine as a yellow oil. Yield: 3 g (94%); 1H NMR (400 MHz, DMSO-d6): δ 9.42 (s, 1H), 8.56 (s, 1H); MS (ESI+) m/z 227.34 [M+H]+.

References

[1] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 107; 193; 194
[2] Patent: WO2006/65703, 2006, A1. Location in patent: Page/Page column 108
[3] Patent: US2003/69257, 2003, A1

4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-5-nitro-2-(trifluoroMethyl)pyridine Suppliers

China 36 India 1 United Kingdom 1 United States 5 Global 43

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438554-45-1, 4-Chloro-5-nitro-2-(trifluoroMethyl)pyridineRelated Search:

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438554-45-1