3,6-dibroMopyrazine-2-carboxylic acid
- Product Name
- 3,6-dibroMopyrazine-2-carboxylic acid
- CAS No.
- 957230-68-1
- Chemical Name
- 3,6-dibroMopyrazine-2-carboxylic acid
- Synonyms
- 3,6-dibroMopyrazine-2-carboxylic acid;3,6-dibromo-2-Pyrazinecarboxylic acid;2-Pyrazinecarboxylic acid, 3,6-dibromo-;2-Pyrazinamine, 5-bromo-3-(bromomethyl)-,hydrobromide (1:1)
- CBNumber
- CB82595715
- Molecular Formula
- C5H2Br2N2O2
- Formula Weight
- 281.89
- MOL File
- 957230-68-1.mol
3,6-dibroMopyrazine-2-carboxylic acid Property
- Boiling point:
- 368.7±42.0 °C(Predicted)
- Density
- 2.333±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.17±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- D426233
- Product name
- 3,6-Dibromopyrazine-2-carboxylicAcid
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FD153727
- Product name
- 3,6-Dibromopyrazine-2-carboxylic acid
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FD153727
- Product name
- 3,6-Dibromopyrazine-2-carboxylic acid
- Packaging
- 500mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- J97939
- Product name
- 3,6-Dibromopyrazine-2-carboxylicacid
- Packaging
- 10g
- Price
- $342
- Updated
- 2021/12/16
- Product number
- FD153727
- Product name
- 3,6-Dibromopyrazine-2-carboxylic acid
- Packaging
- 1g
- Price
- $400
- Updated
- 2021/12/16
3,6-dibroMopyrazine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
13301-04-7
957230-68-1
General procedure for the synthesis of 3,6-dibromopyrazine-2-carboxylic acid from methyl 3,6-dibromopyrazine-2-carboxylate: a solution of LiOH (121 mg, 5.07 mmol) in water (1 mL) was added slowly and dropwise at 0 °C to methyl 3,6-dibromopyrazine-2-carboxylate (500 mg, 1.67 mmol) dissolved in a 1:1 THF/water (8 mL) solution. The reaction mixture was stirred continuously at 0 °C for 45 min. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in a mixed system of dichloromethane (DCM) and 1N aqueous hydrochloric acid. The organic layer was separated and the aqueous phase was extracted twice with DCM. All organic extracts were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 350 mg (74% yield) of a cream-colored solid product. Mass spectrometry (MS) analysis showed: m/z (ES) 282 (M + H)+.
References
[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 57
[2] Patent: US2009/286798, 2009, A1. Location in patent: Page/Page column 26
[3] Patent: US2011/118269, 2011, A1. Location in patent: Page/Page column 13
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 6, p. 2266 - 2270
[5] Patent: WO2007/131991, 2007, A1. Location in patent: Page/Page column 47-48
3,6-dibroMopyrazine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,6-dibroMopyrazine-2-carboxylic acid manufacturers
- Product
- 3,6-dibroMopyrazine-2-carboxylic acid 957230-68-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02