ChemicalBook > CAS DataBase List > 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-

Product Name
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
CAS No.
1145663-09-7
Chemical Name
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
Synonyms
rel-Boc-Hyp-OMe;N-Boc-trans-4-hydroxy-proline methyl ester;trans-1-Boc-4-hydroxypyrolidine-2-carboxylic acidmethyl ester;Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
CBNumber
CB82597724
Molecular Formula
C11H19NO5
Formula Weight
245.27
MOL File
1145663-09-7.mol
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Property

Boiling point:
335.2±42.0 °C(Predicted)
Density 
1.216±0.06 g/cm3(Predicted)
pka
14.27±0.40(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
AAA0010286
Product name
(2R,4S)-1-TERT-BUTYL 2-METHYL-4-HYDROXYPYRROLIDINE-1,2-DICARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$499.97
Updated
2021/12/16
Alichem
Product number
1145663097
Product name
trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
Packaging
25g
Price
$594
Updated
2021/12/16
Crysdot
Product number
CD21018375
Product name
trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
Purity
97%
Packaging
25g
Price
$600
Updated
2021/12/16
Crysdot
Product number
CD21018375
Product name
trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
Purity
97%
Packaging
1g
Price
$60
Updated
2021/12/16
Crysdot
Product number
CD21018375
Product name
trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
Purity
97%
Packaging
5g
Price
$180
Updated
2021/12/16
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Chemical Properties,Usage,Production

Uses

rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Suppliers

China 9 United States 1 Global 10
Shanghai Xingui Biotechnology Co., Ltd.
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15121041756
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China
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TaiChem Taizhou Limited
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052386810091
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+86-0571-81612335 +8613336028439
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sales@nextpeptide.com
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Hebei Chishuo Biotechnology Co., Ltd.
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Shanghai Xinxin Pharmaceutical Technology Co., Ltd.
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Shanghai Haohong Pharmaceutical Co., Ltd.
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Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
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Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.
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025-66061636 18013972705
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Guangzhou Yiran Biotechnology Co., Ltd.
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15571990006
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1145663-09-7, 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-Related Search:

(3R,4R)-1-tert-butyl 3,4-diethyl pyrrolidine-1,3,4-tricarboxylate Ethyl trans-1-Boc-4-hydroxypyrrolidine-3-carboxylate TRANS-4-AMINO-1-N-BOC-3-PYRROLIDINECARBOXYLIC ACID ETHYL ESTER

  • 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
  • Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • rel-Boc-Hyp-OMe
  • N-Boc-trans-4-hydroxy-proline methyl ester
  • trans-1-Boc-4-hydroxypyrolidine-2-carboxylic acidmethyl ester
  • 1145663-09-7