ChemicalBook > CAS DataBase List > 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
- Product Name
- 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
- CAS No.
- 1145663-09-7
- Chemical Name
- 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
- Synonyms
- rel-Boc-Hyp-OMe;N-Boc-trans-4-hydroxy-proline methyl ester;Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-
- CBNumber
- CB82597724
- Molecular Formula
- C11H19NO5
- Formula Weight
- 245.27
- MOL File
- 1145663-09-7.mol
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Property
- Boiling point:
- 335.2±42.0 °C(Predicted)
- Density
- 1.216±0.06 g/cm3(Predicted)
- pka
- 14.27±0.40(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- AAA0010286
- Product name
- (2R,4S)-1-TERT-BUTYL 2-METHYL-4-HYDROXYPYRROLIDINE-1,2-DICARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.97
- Updated
- 2021/12/16
Alichem
- Product number
- 1145663097
- Product name
- trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
- Packaging
- 25g
- Price
- $594
- Updated
- 2021/12/16
Crysdot
- Product number
- CD21018375
- Product name
- trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $600
- Updated
- 2021/12/16
Crysdot
- Product number
- CD21018375
- Product name
- trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
Crysdot
- Product number
- CD21018375
- Product name
- trans-1-tert-Butyl2-methyl4-hydroxypyrrolidine-1,2-dicarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Chemical Properties,Usage,Production
Uses
rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Preparation Products And Raw materials
Raw materials
Preparation Products
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1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Suppliers
- Tel
- --
- Fax
- --
- sales@combi-blocks.com
- Country
- United States
- ProdList
- 6618
- Advantage
- 69
1145663-09-7, 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-Related Search:
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