ChemicalBook > CAS DataBase List > A 804598

A 804598

Product Name
A 804598
CAS No.
1125758-85-1
Chemical Name
A 804598
Synonyms
CS-2234;A 804598;A-804598 ，S8725;A-804598 （(A 804598;A-804598, 10 mM in DMSO;S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine;2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine;N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine;Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
CBNumber
CB82602998
Molecular Formula
C19H17N5
Formula Weight
315.37
MOL File
1125758-85-1.mol
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A 804598 Property

Boiling point:
498.0±47.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
4.52±0.12(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0617
Product name
A-804598
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0617
Product name
A-804598
Purity
≥98% (HPLC)
Packaging
25mg
Price
$496
Updated
2025/07/31
Cayman Chemical
Product number
20060
Product name
A-804598
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
20060
Product name
A-804598
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
20060
Product name
A-804598
Purity
≥98%
Packaging
25mg
Price
$412
Updated
2024/03/01
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A 804598 Chemical Properties,Usage,Production

Uses

A 804598 is a P2X7 antagonist.

Biological Activity

a 804598 is a potent and selective antagonist of p2x7 receptor with ic50 values of 8.9, 9.9 and 10.9 nm for mouse, rat and human p2x7 receptors, respectively [1].p2x purinoceptor 7 (p2x7 receptor) is a purinoceptor and is activated by high concentrations of atp. p2x7 receptor plays an important role in atp-mediated cell death, inflammation and regulation of receptor trafficking.a 804598 is a potent and selective p2x7 receptor antagonist. in differentiated thp-1 cells that expressed human p2x7 receptors, a 804598 inhibited bzatp stimulated yo-pro uptake and release of il-1β. in 1321n1 cells expressed recombinant rat p2x7 receptor, a 804598 showed high affinity with kd = 2.4 nm [1]. a 804598 inhibited bz-atp stimulated calcium influx with ic50 value of 28.71 nm in a concentration-dependent way. a-804598 was a potent p2x7 receptor antagonist with ki value of 7.51 nm [2].in adult male rats, footshock increased the mrna levels of cd14 and il-1β in the paraventricular nucleus. while a-804598 (25 mg/kg) partially inhibited these effects [3].

in vivo

A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease[3].

Animal Model:Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice [3]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; five times a week
Result:Decreased SQSTM1/p62 expression.

IC 50

P2X7 Receptor

storage

Store at -20°C

References

[1]. donnelly-roberts dl, namovic mt, surber b, et al. [3h]a-804598 ([3h]2-cyano-1-[(1s)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for p2x7 receptors. neuropharmacology, 2009, 56(1): 223-229.
[2]. able sl, fish rl, bye h, et al. receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant p2x7 antagonists in the rat. br j pharmacol. 2011, 162(2): 405-414.
[3]. catanzaro jm1, hueston cm, deak mm, et al. the impact of the p2x7 receptor antagonist a-804598 on neuroimmune and behavioral consequences of stress. behav pharmacol, 2014, 25(5-6): 582-598.

A 804598 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 804598 Suppliers

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View Lastest Price from A 804598 manufacturers

Career Henan Chemical Co
Product
A 804598 1125758-85-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

1125758-85-1, A 804598Related Search:


  • A 804598
  • N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine
  • 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine
  • 2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine
  • A-804598 （(A 804598
  • CS-2234
  • Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
  • S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine
  • A-804598, 10 mM in DMSO
  • A-804598 ，S8725
  • 1125758-85-1