A 804598
- Product Name
- A 804598
- CAS No.
- 1125758-85-1
- Chemical Name
- A 804598
- Synonyms
- CS-2234;A 804598;A-804598 ((A 804598;S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine;2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine;N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine;Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-
- CBNumber
- CB82602998
- Molecular Formula
- C19H17N5
- Formula Weight
- 315.37
- MOL File
- 1125758-85-1.mol
A 804598 Property
- Boiling point:
- 498.0±47.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 4.52±0.12(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0617
- Product name
- A-804598
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- SML0617
- Product name
- A-804598
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $481
- Updated
- 2024/03/01
- Product number
- 20060
- Product name
- A-804598
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 20060
- Product name
- A-804598
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 20060
- Product name
- A-804598
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $412
- Updated
- 2024/03/01
A 804598 Chemical Properties,Usage,Production
Uses
A 804598 is a P2X7 antagonist.
Biological Activity
a 804598 is a potent and selective antagonist of p2x7 receptor with ic50 values of 8.9, 9.9 and 10.9 nm for mouse, rat and human p2x7 receptors, respectively [1].p2x purinoceptor 7 (p2x7 receptor) is a purinoceptor and is activated by high concentrations of atp. p2x7 receptor plays an important role in atp-mediated cell death, inflammation and regulation of receptor trafficking.a 804598 is a potent and selective p2x7 receptor antagonist. in differentiated thp-1 cells that expressed human p2x7 receptors, a 804598 inhibited bzatp stimulated yo-pro uptake and release of il-1β. in 1321n1 cells expressed recombinant rat p2x7 receptor, a 804598 showed high affinity with kd = 2.4 nm [1]. a 804598 inhibited bz-atp stimulated calcium influx with ic50 value of 28.71 nm in a concentration-dependent way. a-804598 was a potent p2x7 receptor antagonist with ki value of 7.51 nm [2].in adult male rats, footshock increased the mrna levels of cd14 and il-1β in the paraventricular nucleus. while a-804598 (25 mg/kg) partially inhibited these effects [3].
storage
Store at -20°C
References
[1]. donnelly-roberts dl, namovic mt, surber b, et al. [3h]a-804598 ([3h]2-cyano-1-[(1s)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for p2x7 receptors. neuropharmacology, 2009, 56(1): 223-229.
[2]. able sl, fish rl, bye h, et al. receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant p2x7 antagonists in the rat. br j pharmacol. 2011, 162(2): 405-414.
[3]. catanzaro jm1, hueston cm, deak mm, et al. the impact of the p2x7 receptor antagonist a-804598 on neuroimmune and behavioral consequences of stress. behav pharmacol, 2014, 25(5-6): 582-598.
A 804598 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from A 804598 manufacturers
- Product
- A 804598 1125758-85-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20