NDT 9513727

Product Name: NDT 9513727
CAS No.: 439571-48-9
Chemical Name: NDT 9513727
Synonyms: NDT 9513727;N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine;1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-
CBNumber: CB82603001
Molecular Formula: C36H35N3O4
Formula Weight: 573.68
MOL File: 439571-48-9.mol

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NDT 9513727 Property

Boiling point:: 723.1±62.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mM; Ethanol: 100 mM
form: A solid
pka: 6.69±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24448
Product name: NDT 9513727
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24448
Product name: NDT 9513727
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24448
Product name: NDT 9513727
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Tocris

Product number: 3333
Product name: NDT9513727
Purity: ≥98%(HPLC)
Packaging: 10
Price: $278
Updated: 2021/12/16

Tocris

Product number: 3333
Product name: NDT9513727
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1170
Updated: 2021/12/16

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NDT 9513727 Chemical Properties,Usage,Production

Description

NDT 9513727 is a competitive antagonist of the C5a receptor (C5aR; IC₅₀ = 11.6 nM for human recombinant receptors) that has inverse agonist activity in a GTPγ[³⁵S] assay. It is selective for human recombinant over rat and mouse recombinant C5aRs (IC₅₀ = >10 μM for both) but does have activity at macaque and gerbil receptors (IC₅₀s = 7.3 and 6.4 nM, respectively). NDT 9513727 inhibits degranulation in U937 cells stimulated with C5a (IC₅₀ = 7.1 nM). It also prevents neutropenia induced by human recombinant C5a in gerbils (ED₅₀ = 2.2 mg/kg) and in cynomolgus macaques when administered at doses of 5 and 25 mg/kg.

Uses

NDT 9513727 is a selective, and potent inverse agonist of the human C5aR. NDT 9513727 has been shown to effectively inhibit C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo. These results suggest that NDT 9513727 is a promising candidate for the treatment of human inflammatory diseases.

storage

Store at +4°C

NDT 9513727 Preparation Products And Raw materials

Raw materials

Preparation Products

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NDT 9513727 Suppliers

Canada 1 China 26 India 1 United Kingdom 1 United States 7 Global 36

J & K SCIENTIFIC LTD.

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439571-48-9, NDT 9513727Related Search:

NDT 9513727

N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine

1H-Imidazole-5-methanamine, N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-

439571-48-9

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