2,4-difluoro-5-nitropyridine

Product Name: 2,4-difluoro-5-nitropyridine
CAS No.: 60186-15-4
Chemical Name: 2,4-difluoro-5-nitropyridine
Synonyms: 4-difluoro-5-nitropyridine;2,4-difluoro-5-nitropyridine;Pyridine, 2,4-difluoro-5-nitro-
CBNumber: CB82603364
Molecular Formula: C5H2F2N2O2
Formula Weight: 160.08
MOL File: 60186-15-4.mol

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2,4-difluoro-5-nitropyridine Property

Melting point:: 42 °C
Boiling point:: 246.0±35.0 °C(Predicted)
Density: 1.555±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -5.60±0.18(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: D456353
Product name: 2,4-difluoro-5-nitropyridine
Packaging: 50mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D456353
Product name: 2,4-difluoro-5-nitropyridine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104690
Product name: 2,4-difluoro-5-nitropyridine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104690
Product name: 2,4-difluoro-5-nitropyridine
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104690
Product name: 2,4-difluoro-5-nitropyridine
Packaging: 1g
Price: $200
Updated: 2021/12/16

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2,4-difluoro-5-nitropyridine Chemical Properties,Usage,Production

Synthesis

4487-56-3

60186-15-4

General procedure for the synthesis of 2,4-difluoro-5-nitropyridine from 2,4-dichloro-5-nitropyridine: In a 250 mL round-bottomed flask, 2,4-dichloro-5-nitropyridine (0.73 g, 3.8 mmol), potassium fluoride (0.659 g, 11.3 mmol) and 18-crown-6 (0.160 g, 0.605 mmol) were added to an N-methyl pyrrolidone (3 mL) solution to form a brown suspension. The reaction mixture was heated to reflux at 100 °C under nitrogen atmosphere for 3 hours. Upon completion of the reaction, the mixture was partitioned between water and a mixed ether/hexane solvent. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the brown solid product 2,4-difluoro-5-nitropyridine (0.515 g, 85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ 9.07 (d, J = 9.7 Hz, 1H), 6.96 (dd, J = 9.5, 2.5 Hz, 1H) and 19F NMR (376 MHz, CDCl3) δ -52.20 (d, J = 29.3 Hz), -98.13 (d, J = 28.9 Hz).

References

[1] Patent: WO2015/69594, 2015, A1. Location in patent: Page/Page column 106
[2] Patent: WO2018/98413, 2018, A1. Location in patent: Page/Page column 16
[3] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 94; 95

2,4-difluoro-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-difluoro-5-nitropyridine Suppliers

China 59 India 1 United Kingdom 2 United States 5 Global 67

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View Lastest Price from 2,4-difluoro-5-nitropyridine manufacturers

Career Henan Chemical Co

Product: 2,4-difluoro-5-nitropyridine 60186-15-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

60186-15-4, 2,4-difluoro-5-nitropyridineRelated Search:

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Pyridine, 2,4-difluoro-5-nitro-

60186-15-4