(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride

Uses

Product Name: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride
CAS No.: 1147103-42-1
Chemical Name: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride
Synonyms: OHPE Hcl;Telaprevir INT2;Telaprevir InterMediate -1;Ethyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxyla...;(1S,3aR,6aS)Ethyl octahydrocyclopenta[c]pyrrol-1-carboxylate HCl;(1S,3R,6S)-Ethyl Octahydrocyclopenta[c] pyrrole-1-carboxylate HCL;(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate HCL;CYCLOPENTA(C)PYRROLE-1-CARBOXYLIC ACID,OCTAHYDRO-ETHYL ESTERHYDROCHLORIDE;(1S,3aR,6aS)-Octahydro-cyclopentacpyrrol-1-carboxylic acid ethyl ester HCl;(1S,3aR,6aS)-ethyloctahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
CBNumber: CB82604220
Molecular Formula: C10H18ClNO2
Formula Weight: 219.71
MOL File: 1147103-42-1.mol

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(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride Property

storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid
InChI: InChI=1/C10H17NO2.ClH/c1-2-13-10(12)9-8-5-3-4-7(8)6-11-9;/h7-9,11H,2-6H2,1H3;1H/t7-,8-,9-;/s3
InChIKey: CHVSZCHUIDYZIU-ZIEWZEMVNA-N
SMILES: C([C@H]1NC[C@]2([H])CCC[C@]12[H])(=O)OCC.Cl |&1:1,4,9,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: AK143277
Product name: (1S,3aR,6aS)-Ethyloctahydrocyclopenta[c]pyrrole-1-carboxylatehydrochloride
Purity: 95%
Packaging: 1g
Price: $33
Updated: 2021/12/16

ChemScene

Product number: CS-M2271
Product name: Cyclopenta[c]pyrrole-1-carboxylicacid,octahydro-,ethylester,hydrochloride(1:1),(1S,3aR,6aS)-
Purity: ≥98.0%
Packaging: 10g
Price: $178
Updated: 2021/12/16

AK Scientific

Product number: 2423AA
Product name: (1S,3aR,6aS)-Ethyloctahydrocyclopenta[c]pyrrole-1-carboxylate
Packaging: 5g
Price: $239
Updated: 2021/12/16

ChemScene

Product number: CS-M2271
Product name: Cyclopenta[c]pyrrole-1-carboxylicacid,octahydro-,ethylester,hydrochloride(1:1),(1S,3aR,6aS)-
Purity: ≥98.0%
Packaging: 25g
Price: $425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032321
Product name: (1S,3AR,6AS)-ETHYL OCTAHYDROCYCLOPENTA[C]PYRROLE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $501.53
Updated: 2021/12/16

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(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride Chemical Properties,Usage,Production

Uses

(1S,3AR,6AS)-octahydrocyclopenteno[C]pyrrole-1-carboxylic acid ethyl ester hydrochloride is a carboxylate derivative, mainly used as a pharmaceutical intermediate.

Synthesis

1053232-60-2

1147103-42-1

Compound A of the present invention can be prepared by a conventional aminoprotection method to obtain the known telaprevir intermediate A. In this method, when the aminoprotecting group P is a tert-butoxycarbonyl group, the procedure is as follows: under argon protection, compound I is slowly added to an ethyl acetate solution (69.9 g) containing 11 wt% hydrogen chloride cooled to 0°C. The reaction is carried out by stirring for 4 hours. After the addition was completed, the reaction system was warmed to 30-35°C and stirred continuously at this temperature for 4 hours to ensure complete reaction. Upon completion of the reaction, the reaction solution was concentrated to dryness by distillation under reduced pressure. Subsequently, methyl tert-butyl ether (80 mL) was added to the residue at room temperature, stirred for 1 hour and then filtered. The filter cake was dried under vacuum to constant weight to give a white to off-white solid, timosartan intermediate A, in a yield of 15.4 g with 99.5% HPLC purity. The overall four-step molar yield from compound II to intermediate A was 70%.

References

[1] Patent: CN106928123, 2017, A. Location in patent: Paragraph 0085-0089

(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride Suppliers

China 98 India 1 United States 6 Global 105

Anhui Nature Pharmaceutical Co., Ltd.

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Energy Chemical

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Bide Pharmatech Ltd.

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View Lastest Price from (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride 1147103-42-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: OHPE Hcl 1147103-42-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: OHPE Hcl 1147103-42-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1147103-42-1, (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochlorideRelated Search:

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(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride

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1147103-42-1 (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride

ethyl (3S,3aS,6aR)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-3-carboxylate

(1S,3aR,6aS)-octahydro-Cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride (1:1)

(1S,3aR,6aS)-Octahydro-cyclopentacpyrrol-1-carboxylic acid ethyl ester HCl

ethyl (3S,3aS,6aR)-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole-3-carboxylate hydrochloride

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate HCL

(1S,3aR,6aS)Ethyl octahydrocyclopenta[c]pyrrol-1-carboxylate HCl

1147103-42-1

Telaprevir intermediate