(R)-2-ethylpyrrolidine hydrochloride

Product Name: (R)-2-ethylpyrrolidine hydrochloride
CAS No.: 460748-80-5
Chemical Name: (R)-2-ethylpyrrolidine hydrochloride
Synonyms: (2R)-2-ETHYL-PYRROLIDINE HCL;(2R)-Ethylpyrrolidine hydrochloride;(R)-2-ethylpyrrolidine hydrochloride;(2R)-2-Ethylpyrrolidine Hydrochloride
CBNumber: CB82604578
Molecular Formula: C6H14ClN
Formula Weight: 135.64
MOL File: 460748-80-5.mol

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(R)-2-ethylpyrrolidine hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E818075
Product name: (2R)-EthylpyrrolidineHydrochloride
Packaging: 2.5g
Price: $1260
Updated: 2021/12/16

AK Scientific

Product number: 8110DT
Product name: (R)-2-Ethylpyrrolidinehydrochloride
Packaging: 5g
Price: $1342
Updated: 2021/12/16

AK Scientific

Product number: 8110DT
Product name: (R)-2-Ethylpyrrolidinehydrochloride
Packaging: 250mg
Price: $282
Updated: 2021/12/16

AK Scientific

Product number: 8110DT
Product name: (R)-2-Ethylpyrrolidinehydrochloride
Packaging: 1g
Price: $492
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0032851
Product name: (R)-2-ETHYLPYRROLIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $499.66
Updated: 2021/12/16

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(R)-2-ethylpyrrolidine hydrochloride Chemical Properties,Usage,Production

Uses

(2R)-Ethylpyrrolidine Hydrochloride is used as a reagent in the synthesis of 6-(4-pyrimidinyl)-1H-indazole derivatives as PDK1 kinase inhibitors useful in treatment of cancer, immune, metabolic and other kinase-mediated diseases. Also used as a reagent in the synthesis of aryloxazole derivatives as histamine H3 receptor antagonists or inverse agonists.

Synthesis

1227910-54-4

460748-80-5

In a sealable reaction tube, phenylmethyl (2R)-2-ethyl-1-pyrrolidinecarboxylate (230 mg, 0.99 mmol) was dissolved in a solvent mixture of 1,4-dioxane (6 mL) and concentrated hydrochloric acid (4 mL). After sealing the reaction tube, the reaction mixture was stirred at 90°C for 5 hours. Upon completion of the reaction, the solution was concentrated and the residue was azeotropized by toluene (~20 mL) to remove residual water. Subsequently, ether (Et2O) was added to the residue and the mixture was sonicated and decanted. The solid obtained was dissolved in acetonitrile (CH3CN) and ether was added dropwise until a precipitate was generated. The mixture was again sonicated and decanted, and the solid was ground with ether to give (R)-2-ethylpyrrolidine hydrochloride (80 mg, 60% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, CD3OD): δ 1.07 (t, J = 7.5 Hz, 3H), 1.60-1.84 (m, 3H), 1.96-2.17 (m, 2H), 2.19-2.31 (m, 1H), 3.30 (m, 2H), 3.38-3.52 (m, 1H).

References

[1] Patent: WO2010/120854, 2010, A1. Location in patent: Page/Page column 55

(R)-2-ethylpyrrolidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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460748-80-5, (R)-2-ethylpyrrolidine hydrochlorideRelated Search:

(R)-2-ethylpyrrolidine hydrochloride

(2R)-Ethylpyrrolidine hydrochloride

(2R)-2-Ethylpyrrolidine Hydrochloride

(2R)-2-ETHYL-PYRROLIDINE HCL

460748-80-5