3-(2-fluoro-4-iodophenylaMino)isonicotinic acid

Product Name: 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid
CAS No.: 885588-03-4
Chemical Name: 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid
Synonyms: 100537;3-(2-fluoro-4-iodophenylaMino)isonicotinic acid;3-(2-Fluoro-4-iodoanilino)pyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 3-[(2-fluoro-4-iodophenyl)amino]-
CBNumber: CB82604644
Molecular Formula: C12H8FIN2O2
Formula Weight: 358.11
MOL File: 885588-03-4.mol

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3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Property

Boiling point:: 484.8±45.0 °C(Predicted)
Density: 1.909±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.39±0.36(Predicted)
Appearance: Light brown to gray Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-B0946
Product name: 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
Packaging: 100mg
Price: $74
Updated: 2021/12/16

ChemScene

Product number: CS-B0946
Product name: 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
Packaging: 250mg
Price: $114
Updated: 2021/12/16

ChemScene

Product number: CS-B0946
Product name: 3-[(2-Fluoro-4-iodophenyl)amino]isonicotinicacid
Packaging: 1g
Price: $280
Updated: 2021/12/16

Matrix Scientific

Product number: 090048
Product name: 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid
Purity: 95+%
Packaging: 250mg
Price: $416
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364018
Product name: 3-((2-FLUORO-4-IODOPHENYL)AMINO)ISONICOTINIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $498.6
Updated: 2021/12/16

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3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Chemical Properties,Usage,Production

Synthesis

393-53-3

885588-03-4

The general procedure for the synthesis of 3-(2-fluoro-4-iodophenylamino)-4-carboxylic acid pyridine from 3-fluoroisonicotinic acid is as follows: Intermediate 1: Synthesis of 3-(2-fluoro-4-iodophenylamino)-isonicotinic acid: 4-Iodo-2-fluoroaniline (20.0 g, 84.38 mmol) was dissolved in anhydrous tetrahydrofuran (80 mL) under inert atmosphere and cooled to -65 °C. Subsequently, 1.0 M bis(trimethylsilyl)aminolithium tetrahydrofuran solution (255 mL, 255 mmol) was slowly added, keeping the reaction temperature below -55 °C. After addition, the reaction mixture was stirred for 30 min, then 3-fluoroisonicotinic acid (8.0 g, 56.69 mmol) was added. The reaction mixture was stirred at room temperature for 4 days. After the reaction was completed, the mixture was poured into 2.0 N aqueous sodium hydroxide solution (1000 mL) and ethyl acetate (250 mL). The organic and aqueous layers were separated and the aqueous layer was further extracted from the organic phase with aqueous sodium hydroxide solution (2 x 1000 mL). The aqueous phase was combined and the pH was adjusted to 2 with concentrated hydrochloric acid to precipitate the target product. The solid was collected by filtration, washed with water (300 mL) and dried under high vacuum at 40 °C for 18 h to afford the yellow solid product 3-(2-fluoro-4-iodophenylamino)-isonicotinic acid (19.05 g, 53.19 mmol, 94% yield). Mass spectrum (MS): [M+1] 359. 1H NMR (400 MHz, DMSO-D6): δ 7.3565 (t, J = 8.8 Hz, 1H), 7.5509 (d, J = 8.4 Hz, 1H), 7.7521 (m, 2H), 8.1175 (d, J = 4.7 Hz, 1H), 8.4472 (s, 1H), 9.2184 (s, 1H).

References

[1] Patent: WO2007/123936, 2007, A1. Location in patent: Page/Page column 36

3-(2-fluoro-4-iodophenylaMino)isonicotinic acid Preparation Products And Raw materials

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View Lastest Price from 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid manufacturers

Career Henan Chemical Co

Product: 3-(2-fluoro-4-iodophenylaMino)isonicotinic acid 885588-03-4
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-17

885588-03-4, 3-(2-fluoro-4-iodophenylaMino)isonicotinic acidRelated Search:

3-(2-fluoro-4-iodophenylaMino)isonicotinic acid

100537

4-Pyridinecarboxylic acid, 3-[(2-fluoro-4-iodophenyl)amino]-

3-(2-Fluoro-4-iodoanilino)pyridine-4-carboxylic acid

885588-03-4

C12H8FIN2O2