2,6-dibroMo-3-Methoxypyridine
- Product Name
- 2,6-dibroMo-3-Methoxypyridine
- CAS No.
- 79491-45-5
- Chemical Name
- 2,6-dibroMo-3-Methoxypyridine
- Synonyms
- 2,6-dibroMo-3-Methoxypyridine;2,6-dibromo-3-methoxylpyridine;Pyridine, 2,6-dibromo-3-methoxy-
- CBNumber
- CB82605984
- Molecular Formula
- C6H5Br2NO
- Formula Weight
- 266.92
- MOL File
- 79491-45-5.mol
2,6-dibroMo-3-Methoxypyridine Property
- Melting point:
- 99-100 °C(Solv: hexane (110-54-3))
- Boiling point:
- 294.5±35.0 °C(Predicted)
- Density
- 1.919±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -7.50±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H5Br2NO/c1-10-4-2-3-5(7)9-6(4)8/h2-3H,1H3
- InChIKey
- JFWDQTIVECPBDE-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC(Br)=CC=C1OC
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D15668
- Product name
- 2,6-Dibromo-3-methoxypyridine
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- D15668
- Product name
- 2,6-Dibromo-3-methoxypyridine
- Packaging
- 5g
- Price
- $295
- Updated
- 2021/12/16
- Product number
- 5779AQ
- Product name
- 2,6-dibromo-3-methoxypyridine
- Packaging
- 1g
- Price
- $300.8
- Updated
- 2021/12/16
- Product number
- HCH0362897
- Product name
- 2,6-DIBROMO-3-METHOXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.91
- Updated
- 2021/12/16
- Product number
- A164095
- Product name
- 2,6-Dibromo-3-methoxypyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
2,6-dibroMo-3-Methoxypyridine Chemical Properties,Usage,Production
Synthesis
6602-33-1
74-88-4
79491-45-5
2,6-Dibromo-3-hydroxypyridine (12 g, 47 mmol) was used as starting material and mixed with potassium carbonate (6.0 g, 43 mmol) and iodomethane (10.1 mL, 162 mmol) in DMSO (20 mL) to form a suspension. The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was poured into water (60 mL), gently heated at 50 °C and stirred for 30 min. Subsequently, the reaction mixture was cooled to room temperature and the precipitated solid was collected by filtration and dried under vacuum. Finally, the dried residue was crystallized from cyclohexane to afford the target product 2,6-dibromo-3-methoxypyridine (10.1 g, 80% yield) as a light orange solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ= 7.66 (d, J = 8.0 Hz, 1H), 7.52 (d, J = 8.0 Hz, 1H), 3.90 (s, 3H); mass spectrometry analysis showed ES + ve m/z 266,268,270 (M + H)+.
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 15, p. 4298 - 4311
[2] Australian Journal of Chemistry, 1981, vol. 34, # 4, p. 927 - 932
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5630 - 5634
[4] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0088; 0089
[5] Patent: EP2017277, 2009, A1. Location in patent: Page/Page column 30
2,6-dibroMo-3-Methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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