(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione

ChemicalBook > CAS DataBase List > (E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione

(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione

Product Name: (E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione
CAS No.: 423148-78-1
Chemical Name: (E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione
Synonyms: PYZD 4409;PYZD4409;PYZD 4409;PYZD-4409 >=98% (HPLC);PYZD-4409, 10 mM in DMSO;1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-;(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione;Inhibitor,PYZD 4409,E3 ligating enzyme,E2 conjugating enzyme,PYZD-4409,inhibit,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,E1 activating enzyme,Ubiquitin ligase,Ubiquitin conjugating enzyme,PYZD4409;(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione 3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-
CBNumber: CB82609290
Molecular Formula: C14H7ClFN3O5
Formula Weight: 351.67
MOL File: 423148-78-1.mol

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(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione Property

Density: 1.662±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: solid
pka: 7.12±0.20(Predicted)
color: Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 4994
Product name: PYZD4409
Purity: ≥98%(HPLC)
Packaging: 10
Price: $216
Updated: 2021/12/16

Tocris

Product number: 4994
Product name: PYZD4409
Purity: ≥98%(HPLC)
Packaging: 50
Price: $906
Updated: 2021/12/16

Usbiological

Product number: 256376
Product name: PYZD 4409
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-1725
Product name: PYZD-4409
Purity: >98.0%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

ApexBio Technology

Product number: B1244
Product name: PYZD-4409
Packaging: 10mg
Price: $557
Updated: 2021/12/16

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(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione Chemical Properties,Usage,Production

Biological Activity

pyzd-4409 is a novel small molecule inhibitor of the ubiquitin-activating enzyme e1 with ic50 value of 20μm [1].the ubiquitin-activating enzyme e1 is involved in the fist step of protein degradation. it uses atp to adenylate and transfers the ubiquitin molecule to the next enzyme e2. it is demonstrated that the ubiquitination pathway is increased in the primary leukemia cells. thus, inhibition of e1 can be a target of hematologic malignancies treatment. pyzd-4409 is screened out from a chemical library based on the pyrazolidine pharmacophore. the ic50 value(20μm) of it has been evaluated in a cell-free enzymatic assay. pyzd-4409 can also inhibit e1 in cultured k562 leukemia cells. pyzd-4409 causes cell death in leukemia, myeloma and solid tumor cell lines. in clonogenic growth assays, pyzd-4409 is found to reduce the growth of aml cells over normal hematopoietic cells. as an essential role of protein degradation, the inhibition of e1 resluts in the increased amounts of cyclin d3 and p53 [1].

References

[1] g. wei xu, mohsin ali, tabitha e. wood et al. the ubiquitin-activating enzyme e1 as a therapeutic target for the treatment of leukemia and multiple myeloma. blood. 2010, 115(11): 2251-2259.

(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione Suppliers

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423148-78-1, (E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dioneRelated Search:

(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione

PYZD 4409

(E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)Methylene)pyrazolidine-3,5-dione 3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-

PYZD4409;PYZD 4409

1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione

3,5-Pyrazolidinedione, 1-(3-chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-

PYZD-4409 >=98% (HPLC)

Inhibitor,PYZD 4409,E3 ligating enzyme,E2 conjugating enzyme,PYZD-4409,inhibit,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,E1 activating enzyme,Ubiquitin ligase,Ubiquitin conjugating enzyme,PYZD4409

PYZD-4409, 10 mM in DMSO

423148-78-1

C14H7ClFN3O5