1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Product Name
- 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- CAS No.
- 888721-65-1
- Chemical Name
- 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Synonyms
- 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine;1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxylic acid;1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-
- CBNumber
- CB82609351
- Molecular Formula
- C13H10FNO3
- Formula Weight
- 247.22
- MOL File
- 888721-65-1.mol
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Property
- Boiling point:
- 431.4±45.0 °C(Predicted)
- Density
- 1.394±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.21±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 310781
- Product name
- 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Packaging
- 250.00mg
- Price
- $69
- Updated
- 2026/05/19
- Product number
- 310781
- Product name
- 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Packaging
- 1.00g
- Price
- $171
- Updated
- 2026/05/19
- Product number
- 310781
- Product name
- 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Packaging
- 5.00g
- Price
- $506
- Updated
- 2026/05/19
- Product number
- F26220
- Product name
- 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $68
- Updated
- 2026/05/06
- Product number
- F26220
- Product name
- 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2026/05/06
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production
Synthesis
104330-60-1
51731-17-0
888721-65-1
General procedure for the preparation of 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid: to a 4-necked, 3L round-bottomed flask were added ethanol (1500 mL), ethyl 3-((4-fluorophenyl)amino)-3-oxopropanoate (139 g, 617 mmol), sodium ethoxide (65.6 g, 925 mmol), and trans-4-methoxy-3 -buten-2-one (103 g, 925 mmol). The reaction mixture was refluxed for 3 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated under reduced pressure to remove ethanol. The residue was diluted with dichloromethane (700 mL) and 1 M hydrochloric acid (1500 mL). The aqueous phase was extracted with dichloromethane (3 x 500 mL). The organic extracts were combined, washed with saturated aqueous sodium chloride (1000 mL), dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The residue was ground with ethyl acetate (150 mL) for 1 hour at room temperature (10-15°C). After filtration and washing with ethyl acetate (50 mL), 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid was obtained as a yellow solid (85.3 g, 56% yield). Mass spectrum (m/z): 248 (M + H).
References
[1] Patent: US2010/22529, 2010, A1. Location in patent: Page/Page column 18
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
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