1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Product Name: 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
CAS No.: 888721-65-1
Chemical Name: 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
Synonyms: 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine;1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxylic acid;1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-
CBNumber: CB82609351
Molecular Formula: C13H10FNO3
Formula Weight: 247.22
MOL File: 888721-65-1.mol

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1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Property

Boiling point:: 431.4±45.0 °C(Predicted)
Density: 1.394±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 2.21±0.20(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 1790AQ
Product name: 1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxylicacid
Packaging: 100mg
Price: $330.8
Updated: 2021/12/16

Chemenu

Product number: CM255591
Product name: 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylicacid
Purity: 95+%
Packaging: 1g
Price: $608
Updated: 2021/12/16

Ambeed

Product number: A363900
Product name: 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylicacid
Purity: 97%
Packaging: 5g
Price: $610
Updated: 2021/12/16

Alichem

Product number: 888721651
Product name: 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylicacid
Packaging: 1g
Price: $682.5
Updated: 2021/12/16

Ambeed

Product number: A363900
Product name: 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylicacid
Purity: 97%
Packaging: 10g
Price: $1036
Updated: 2021/12/16

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1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Chemical Properties,Usage,Production

Synthesis

104330-60-1

51731-17-0

888721-65-1

General procedure for the preparation of 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid: to a 4-necked, 3L round-bottomed flask were added ethanol (1500 mL), ethyl 3-((4-fluorophenyl)amino)-3-oxopropanoate (139 g, 617 mmol), sodium ethoxide (65.6 g, 925 mmol), and trans-4-methoxy-3 -buten-2-one (103 g, 925 mmol). The reaction mixture was refluxed for 3 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated under reduced pressure to remove ethanol. The residue was diluted with dichloromethane (700 mL) and 1 M hydrochloric acid (1500 mL). The aqueous phase was extracted with dichloromethane (3 x 500 mL). The organic extracts were combined, washed with saturated aqueous sodium chloride (1000 mL), dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The residue was ground with ethyl acetate (150 mL) for 1 hour at room temperature (10-15°C). After filtration and washing with ethyl acetate (50 mL), 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid was obtained as a yellow solid (85.3 g, 56% yield). Mass spectrum (m/z): 248 (M + H).

References

[1] Patent: US2010/22529, 2010, A1. Location in patent: Page/Page column 18

1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Suppliers

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888721-65-1, 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acidRelated Search:

1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxylic acid

3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-

1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine

888721-65-1